Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Graves' disease
ADR ID BADD_A09992
ADR Hierarchy
05      Endocrine disorders
05.02      Thyroid gland disorders
05.02.02      Thyroid hyperfunction disorders
05.02.02.009      Graves' disease
10      Immune system disorders
10.04      Autoimmune disorders
10.04.08      Endocrine autoimmune disorders
10.04.08.014      Graves' disease
06      Eye disorders
06.09      Ocular structural change, deposit and degeneration NEC
06.09.04      Structural change, deposit and degeneration of eye NEC
06.09.04.009      Graves' disease
Description A common form of hyperthyroidism with a diffuse hyperplastic GOITER. It is an autoimmune disorder that produces antibodies against the THYROID STIMULATING HORMONE RECEPTOR. These autoantibodies activate the TSH receptor, thereby stimulating the THYROID GLAND and hypersecretion of THYROID HORMONES. These autoantibodies can also affect the eyes (GRAVES OPHTHALMOPATHY) and the skin (Graves dermopathy). [MeSH]
MedDRA Code 10018706
MeSH ID D006111
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Basedow's disease | Disease Graves' | Exophthalmic goiter | Exophthalmic goitre | Goiter exophthalmic | Graves' disease | Toxic diffuse goiter | Toxic diffuse goiter without mention of thyrotoxic crisis or storm | Toxic diffuse goitre | Graves-Basedow disease | Autoimmune hyperthyroidism | Goitre exophthalmic | Graves Disease | Disease, Graves | Basedow Disease | Disease, Basedow | Graves' Disease | Disease, Graves' | Exophthalmic Goiter | Exophthalmic Goiters | Goiters, Exophthalmic | Goiter, Exophthalmic | Hyperthyroidism, Autoimmune | Basedow's Disease | Basedows Disease | Disease, Basedow's
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00008Abacavir--
BADD_D00064Alemtuzumab--
BADD_D00066Alendronic acid0.000066%
BADD_D00115Amiodarone0.000404%
BADD_D00165Aripiprazole0.000119%
BADD_D00176Atazanavir--
BADD_D00285Bosentan0.000120%
BADD_D00479Cladribine0.000535%
BADD_D00511Clozapine--
BADD_D00586Darunavir--
BADD_D00704Dolutegravir sodium--
BADD_D00749Efavirenz--
BADD_D00757Eliglustat0.004312%
BADD_D00762Elvitegravir--
BADD_D00766Emtricitabine--
BADD_D00768Enalaprilat0.002026%
BADD_D00788Epoprostenol0.000452%
BADD_D00809Escitalopram0.000019%
BADD_D00857Etravirine--
BADD_D00931Fluorouracil0.000184%
BADD_D00961Fosamprenavir calcium--
BADD_D00981Gabapentin0.000010%
BADD_D01023Glimepiride0.000064%
BADD_D01136Imatinib0.000112%
BADD_D01150Indinavir--
BADD_D01180Iohexol0.007113%
BADD_D01213Isotretinoin0.000257%
BADD_D01242Lamivudine--
BADD_D01253Lenalidomide--
BADD_D01281Levonorgestrel0.001182%
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