Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Amiodarone
Drug ID BADD_D00115
Description Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings.[A36817] Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxicity and possibly death, amiodarone use should be reserved for its approved indications, according to prescribing information.[L3561,L11265,L11286]
Indications and Usage Intravenously, for initiation of treatment and prophylaxis of frequently recurring ventricular fibrillation and hemodynamically unstable ventricular tachycardia in patients refractory to other therapy. Orally, for the treatment of life-threatening recurrent ventricular arrhythmias such as recurrent ventricular fibrillation and recurrent hemodynamically unstable ventricular tachycardia.
Marketing Status Prescription; Discontinued
ATC Code C01BD01
DrugBank ID DB01118
KEGG ID D02910
MeSH ID D000638
PubChem ID 2157
TTD Drug ID D0L5WM
NDC Product Code Not Available
Synonyms Amiodarone | Amiodarona | Amiodarone Hydrochloride | Hydrochloride, Amiodarone | Amiohexal | Aratac | Tachydaron | Corbionax | Cordarone | Amiodarex | Trangorex | Kordaron | Cordarex | L-3428 | L 3428 | L3428 | Ortacrone | Rytmarone | SKF 33134-A | SKF 33134 A | SKF 33134A | Amiobeta | Braxan
Chemical Information
Molecular Formula C25H29I2NO3
CAS Registry Number 1951-25-3
SMILES CCCCC1=C(C2=CC=CC=C2O1)C(=O)C3=CC(=C(C(=C3)I)OCCN(CC)CC)I
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.003--
Abnormal dreams17.15.02.001; 19.02.03.001--Not Available
Abortion spontaneous18.01.04.001--Not Available
Activated partial thromboplastin time prolonged13.01.02.0010.000893%
Acute febrile neutrophilic dermatosis01.02.01.006; 23.03.03.0330.001488%Not Available
Acute hepatic failure09.01.03.0010.000543%Not Available
Acute pulmonary oedema02.05.02.004; 22.01.03.0050.001786%Not Available
Acute respiratory distress syndrome22.01.03.0010.001553%
Acute respiratory failure14.01.04.004; 22.02.06.0010.000233%Not Available
Ageusia07.14.03.003; 17.02.07.0010.000595%Not Available
Agitation17.02.05.012; 19.06.02.0010.002976%
Agranulocytosis01.02.03.001--Not Available
Akinesia17.01.02.003--Not Available
Alanine aminotransferase increased13.03.01.0030.001488%
Alopecia23.02.02.001--
Altered state of consciousness17.02.04.001; 19.07.01.0030.000893%Not Available
Alveolitis22.01.01.001--Not Available
Alveolitis allergic10.01.03.008; 22.01.01.0020.000595%Not Available
Amnesia17.03.02.001; 19.20.01.0010.002976%
Anaemia01.03.02.0010.008334%
Anaemia macrocytic01.03.02.002; 14.12.01.0020.000233%Not Available
Anaphylactic reaction10.01.07.001; 24.06.03.0060.001191%
Anaphylactic shock10.01.07.002; 24.06.02.004--Not Available
Anaphylactoid reaction10.01.07.003; 24.06.03.007--Not Available
Angina pectoris02.02.02.002; 24.04.04.002--
Angioedema10.01.05.009; 23.04.01.001--Not Available
Anxiety19.06.02.0020.008929%
Aplastic anaemia01.03.03.002--Not Available
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ADReCS-Target
Drug Name ADR Term Target
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