Adverse Drug Reaction Classification System-Target Profile (ADReCS-Target) provides comprehensive information for illustrating ADRs caused by drug interactions with protein, gene and genetic variation. ADReCS-Target works independently; however, it serves as a key component of the ADR ontology database ADReCS . ADReCS-Target is also an update of DITOP database and DART database. ADReCS-Target will prompt various ADR studies. It will also be of value to future precision medicine, especially in refining drug with better ADR profile and designing precise drug therapy regimen.