Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Cladribine
Drug ID BADD_D00479
Description An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia.
Indications and Usage For the treatment of active hairy cell leukemia (leukemic reticuloendotheliosis) as defined by clinically significant anemia, neutropenia, thrombocytopenia, or disease-related symptoms. Also used as an alternative agent for the treatment of chronic lymphocytic leukemia (CLL), low-grade non-Hodgkin's lymphoma, and cutaneous T-cell lymphoma.
Marketing Status approved; investigational
ATC Code L01BB04; L04AA40
DrugBank ID DB00242
KEGG ID D01370
MeSH ID D017338
PubChem ID 20279
TTD Drug ID D05GJW
NDC Product Code 42658-010; 12502-5406; 0143-9871; 44087-4000; 54893-0115; 76055-0051; 63323-140; 59605-3006; 65129-1260; 76055-0052; 12502-4912; 58623-0037
UNII 47M74X9YT5
Synonyms Cladribine | 2-Chlorodeoxyadenosine | 2-Chloro-2'-deoxyadenosine | 2'-Deoxy-2-chloroadenosine | Leustatin
Chemical Information
Molecular Formula C10H12ClN5O3
CAS Registry Number 4291-63-8
SMILES C1C(C(OC1N2C=NC3=C(N=C(N=C32)Cl)N)CO)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001---
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.0030.001162%
Abortion spontaneous18.01.04.0010.000841%-
Abscess bacterial11.02.01.027---
Acute myeloid leukaemia01.10.05.001; 16.01.05.0010.000229%-
Acute myocardial infarction02.02.02.001; 24.04.04.0010.000229%-
Acute respiratory distress syndrome10.02.01.067; 22.01.03.001; 24.03.02.0340.000153%
Acute respiratory failure14.01.04.004; 22.02.06.0010.000153%-
Administration site reaction08.02.04.011; 12.07.04.011---
Ageusia07.14.03.003; 17.02.07.001---
Alopecia23.02.02.0010.001682%
Altered state of consciousness17.02.04.001; 19.07.01.003---
Amyloidosis10.02.05.001---
Anaemia01.03.02.001--
Anaphylactic reaction10.01.07.001; 24.06.03.0060.000229%
Angina pectoris02.02.02.002; 24.04.04.002--
Angioedema10.01.05.009; 22.04.02.008; 23.04.01.0010.000306%-
Anxiety19.06.02.002--
Aphasia17.02.03.001; 19.21.01.0010.000153%
Aplastic anaemia01.03.03.002---
Arrhythmia02.03.02.001---
Arthralgia15.01.02.001--
Arthritis15.01.01.001--
Asthenia08.01.01.001---
Asthma10.01.03.010; 22.03.01.0020.000336%-
Ataxia08.01.02.004; 17.02.02.001--
Atrial fibrillation02.03.03.002--
B-cell lymphoma01.15.01.001; 16.28.01.0010.000153%-
Back pain15.03.04.0050.001269%
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ADReCS-Target
Drug Name ADR Term Target
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