Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Hyperkeratosis
ADR ID BADD_A02126
ADR Hierarchy
23      Skin and subcutaneous tissue disorders
23.01      Cornification and dystrophic skin disorders
23.01.01      Hyperkeratoses
23.01.01.001      Hyperkeratosis
Description A disorder characterized by a thickening of the outer layer of the skin. [CTCAE] Localized hyperplasia of the horny layer of the epidermis due to pressure or friction. (Dorland, 27th ed) [MeSH]
MedDRA Code 10020649
MeSH ID D002145; D002146; D007642; D015776
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Acquired keratoderma | Callosities | Callosity | Callus | Corns | Corns and callosities | Cutaneous horn | Erythrokeratoderma | Foot callus | Hard corn | Hyperkeratosis | Keratoderma | Keratoderma, acquired | Keratosis | Skin keratosis | Soft corn | Tyloma | Tylosis | Skin callus | Clavus | Heloma molle
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00036Acitretin--
BADD_D00066Alendronic acid0.000220%
BADD_D00110Aminolevulinic acid--
BADD_D00115Amiodarone--
BADD_D00165Aripiprazole--
BADD_D00193Axitinib0.002619%
BADD_D00195Azathioprine0.000627%
BADD_D00280Bleomycin--
BADD_D00281Bleomycin sulfate--
BADD_D00330Cabozantinib0.002015%
BADD_D00331Cabozantinib s-malate--
BADD_D00344Canagliflozin0.000486%
BADD_D00349Capecitabine0.000772%
BADD_D00417Cetirizine--
BADD_D00418Cetirizine hydrochloride--
BADD_D00424Cevimeline--
BADD_D00425Cevimeline hydrochloride--
BADD_D00436Chlorhexidine gluconate--
BADD_D00513Cobimetinib--
BADD_D00551Cyclosporine--
BADD_D00566Dabrafenib0.002138%
BADD_D00567Dabrafenib mesylate--
BADD_D00706Donepezil--
BADD_D00707Donepezil hydrochloride--
BADD_D00735Duloxetine hydrochloride--
BADD_D00985Gadodiamide0.007113%
BADD_D01022Gliclazide--
BADD_D01103Hydroxychloroquine0.001859%
BADD_D01110Hydroxyurea0.000112%
BADD_D01142Imiquimod0.002063%
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