Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Acitretin
Drug ID BADD_D00036
Description An oral retinoid effective in the treatment of psoriasis. It is the major metabolite of etretinate with the advantage of a much shorter half-life when compared with etretinate.
Indications and Usage Zouboulis CC: Retinoids--which dermatological indications will benefit in the near future? Skin Pharmacol Appl Skin Physiol. 2001 Sep-Oct;14(5):303-15.
Marketing Status Prescription; Discontinued
ATC Code D05BB02
DrugBank ID DB00459
KEGG ID D02754
MeSH ID D017255
PubChem ID 5284513
TTD Drug ID D05QDC
NDC Product Code 42291-088; 0145-0091; 17337-0004; 76055-0001; 71214-0668; 0093-1136; 0093-1135; 58159-058; 42794-081; 42794-080; 0093-1138; 0145-0090; 62147-0145; 42794-083; 42291-086; 71214-0667; 71214-0669; 0378-7020; 0115-1750; 0115-1751; 0115-1752; 71214-0698; 42291-087; 62147-0146; 0378-7023; 17337-0003; 59981-011; 0115-1753
Synonyms Acitretin | Etretin | Isoacitretin | Isoetretin | Ro 10-1670 | Ro 101670 | Ro-10-1670 | Ro101670 | 13-cis-Acitretin | Neotigason | Soriatane | Acitretin, (Z,E,E,E)-Isomer | Ro-13-7652 | Ro137652 | Ro 13-7652 | Ro 137652
Chemical Information
Molecular Formula C21H26O3
CAS Registry Number 55079-83-9
SMILES CC1=CC(=C(C(=C1C=CC(=CC=CC(=CC(=O)O)C)C)C)C)OC
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Acne23.02.01.001--Not Available
Acute myocardial infarction02.02.02.001; 24.04.04.001--Not Available
Ageusia07.14.03.003; 17.02.07.001--Not Available
Aggression19.05.01.001--Not Available
Alanine aminotransferase increased13.03.01.003--
Alcohol abuse19.07.02.007--Not Available
Alcohol intolerance14.02.01.001--
Alcoholism19.07.02.001--Not Available
Alopecia23.02.02.0010.022911%
Anaemia01.03.02.0010.005728%
Angioedema10.01.05.009; 23.04.01.001--Not Available
Anorectal disorder07.03.01.001--Not Available
Anxiety19.06.02.002--
Arthralgia15.01.02.0010.014320%
Arthritis15.01.01.001--
Arthropathy15.01.01.0030.005728%Not Available
Aspartate aminotransferase increased13.03.01.006--
Asthenia08.01.01.001--Not Available
Atrophic vulvovaginitis21.02.01.003--Not Available
Back pain15.03.04.005--
Balanoposthitis21.09.03.001--Not Available
Basal cell carcinoma16.03.02.001; 23.08.02.0010.008592%Not Available
Basophil count increased13.01.06.002--Not Available
Benign intracranial hypertension17.07.02.001--Not Available
Bilirubin conjugated increased13.03.01.007--Not Available
Bleeding time prolonged13.01.02.002--Not Available
Blepharitis06.04.04.001; 23.03.04.012--Not Available
Blindness06.02.02.001; 17.17.01.003--Not Available
Blister12.01.06.002; 23.03.01.0010.008592%Not Available
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