| Drug Name |
Hydroxychloroquine |
| Drug ID |
BADD_D01103 |
| Description |
Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer.[A183047] Hydroxychloroquine is an aminoquinoline like [chloroquine].[L8072] It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus.[L8072] Hydroxychloroquine is also used for the prophylaxis of malaria in regions where chloroquine resistance is unlikely.[L8072] It was developed during World War II as a derivative of [quinacrine] with less severe side effects.[A183092] Chloroquine and hydroxychloroquine are both being investigated for the treatment of SARS-CoV-2.[A192132]
**The FDA emergency use authorization for hydroxychloroquine and [chloroquine] in the treatment of COVID-19 was revoked on 15 June 2020.[L14312]**
Hydroxychloroquine was granted FDA approval on 18 April 1955.[L8072]
A recent study reported a fatality in the group being treated with hydroxychloroquine for COVID-19.[A192546] |
| Indications and Usage |
Hydroxychloroquine is indicated for the prophylaxis of malaria where chloroquine resistance is not reported, treatment of uncomplicated malaria (caused by _P. falciparum_, _P. malariae_, _P. ovale_, or _P. vivax_), chronic discoid lupus erythematosus, systemic lupus erythematosus, acute rheumatoid arthritis, and chronic rheumatoid arthritis.[L8072] |
| Marketing Status |
approved |
| ATC Code |
P01BA02 |
| DrugBank ID |
DB01611
|
| KEGG ID |
D08050
|
| MeSH ID |
D006886
|
| PubChem ID |
3652
|
| TTD Drug ID |
D0OJ4L
|
| NDC Product Code |
Not Available |
| UNII |
4QWG6N8QKH
|
| Synonyms |
Hydroxychloroquine | Oxychlorochin | Oxychloroquine | Hydroxychlorochin | Plaquenil | Hydroxychloroquine Sulfate | Hydroxychloroquine Sulfate (1:1) Salt |
