Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Benign prostatic hyperplasia
ADR ID BADD_A00441
ADR Hierarchy
21      Reproductive system and breast disorders
21.04      Prostatic disorders (excl infections and inflammations)
21.04.02      Prostatic neoplasms and hypertrophy
21.04.02.001      Benign prostatic hyperplasia
Description Increase in constituent cells in the PROSTATE, leading to enlargement of the organ (hypertrophy) and adverse impact on the lower urinary tract function. This can be caused by increased rate of cell proliferation, reduced rate of cell death, or both. | A disease caused by hyperplastic process of non-transformed prostatic cells. [MeSH]
MedDRA Code 10004446
MeSH ID D011470
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Benign prostatic hyperplasia | Benign prostatic hypertrophy | Enlarged prostate (benign) | Hyperplasia of prostate | Hyperplasia of the prostate | Prostatic hyperplasia | Prostatic hypertrophy | Prostatic hypertrophy (benign) | BPH | Prostatic Hyperplasia | Hyperplasia, Prostatic | Prostatic Hypertrophy | Adenoma, Prostatic | Adenomas, Prostatic | Prostatic Adenomas | Prostatic Adenoma | Benign Prostatic Hyperplasia | Prostatic Hyperplasia, Benign | Prostatic Hypertrophy, Benign | Benign Prostatic Hypertrophy | Hypertrophy, Benign Prostatic
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00023Acetaminophen--
BADD_D00033Acetylsalicylic acid0.000044%
BADD_D00066Alendronic acid0.000154%
BADD_D00151Apixaban0.000247%
BADD_D00165Aripiprazole--
BADD_D00271Bicalutamide0.001406%
BADD_D00410Celecoxib--
BADD_D00511Clozapine--
BADD_D00563Dabigatran0.000367%
BADD_D00578Dapagliflozin0.000592%
BADD_D00659Dicyclomine--
BADD_D00706Donepezil--
BADD_D00707Donepezil hydrochloride--
BADD_D00718Doxazosin0.000113%
BADD_D00734Duloxetine0.000040%
BADD_D00765Empagliflozin0.000646%
BADD_D00777Ephedrine--
BADD_D00869Famotidine--
BADD_D00873Fenofibrate0.000039%
BADD_D00891Fesoterodine0.001240%
BADD_D00898Finasteride0.001986%
BADD_D00979Furosemide--
BADD_D01119Ibrutinib0.000526%
BADD_D01136Imatinib0.000112%
BADD_D01217Itraconazole0.004008%
BADD_D01401Metformin0.000011%
BADD_D01475Mirabegron0.000355%
BADD_D01476Mirtazapine0.000080%
BADD_D01530Nandrolone decanoate--
BADD_D01567Nilotinib0.000504%
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