Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Acetylsalicylic acid
Drug ID BADD_D00033
Description Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial infarction (MI) [FDA label]. Interestingly, the results of various studies have demonstrated that long-term use of acetylsalicylic acid may decrease the risk of various cancers, including colorectal, esophageal, breast, lung, prostate, liver and skin cancer [A177325]. Aspirin is classified as a _non-selective cyclooxygenase (COX) inhibitor_ [A32682, A177268] and is available in many doses and forms, including chewable tablets, suppositories, extended release formulations, and others [L5968]. Acetylsalicylic acid is a very common cause of accidental poisoning in young children. It should be kept out of reach from young children, toddlers, and infants [FDA label].
Indications and Usage For use in the temporary relief of various forms of pain, inflammation associated with various conditions (including rheumatoid arthritis, juvenile rheumatoid arthritis, systemic lupus erythematosus, osteoarthritis, and ankylosing spondylitis), and is also used to reduce the risk of death and/or nonfatal myocardial infarction in patients with a previous infarction or unstable angina pectoris.
Marketing Status Prescription; OTC; Discontinued
ATC Code A01AD05; B01AC06; N02BA01
DrugBank ID DB00945
KEGG ID D00109
MeSH ID D001241
PubChem ID 2244
TTD Drug ID D0GY5Z
NDC Product Code 73678-160
Synonyms Aspirin | Acetylsalicylic Acid | Acid, Acetylsalicylic | 2-(Acetyloxy)benzoic Acid | Acylpyrin | Aloxiprimum | Colfarit | Dispril | Easprin | Ecotrin | Endosprin | Magnecyl | Micristin | Polopirin | Polopiryna | Solprin | Solupsan | Zorprin | Acetysal
Chemical Information
Molecular Formula C9H8O4
CAS Registry Number 50-78-2
SMILES CC(=O)OC1=CC=CC=C1C(=O)O
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.0010.000092%Not Available
Abdominal pain07.01.05.0020.000184%
Abdominal pain upper07.01.05.0030.000138%
Abortion spontaneous18.01.04.0010.000092%Not Available
Acidosis14.01.03.002--
Adrenal insufficiency05.01.02.001; 14.11.01.004--
Agitation17.02.05.012; 19.06.02.001--
Anaemia01.03.02.0010.000413%
Anaphylactic shock10.01.07.002; 24.06.02.004--Not Available
Angioedema10.01.05.009; 23.04.01.001--Not Available
Arthralgia15.01.02.001--
Asthenia08.01.01.0010.000138%Not Available
Asthma10.01.03.010; 22.03.01.002--Not Available
Blindness06.02.02.001; 17.17.01.0030.000092%Not Available
Blood cholesterol increased13.12.01.002--
Bradycardia02.03.02.0020.000138%Not Available
Breast feeding26.05.01.001--Not Available
Cardiac arrest02.03.04.0010.000092%
Cardio-respiratory arrest02.03.04.002; 22.02.06.0070.000048%Not Available
Cerebral haemorrhage17.08.01.003; 24.07.04.0010.000132%Not Available
Cerebral infarction17.08.01.004; 24.04.06.0020.000092%Not Available
Cerebrovascular accident17.08.01.007; 24.03.05.0010.000184%
Chest discomfort02.02.02.009; 08.01.08.019; 22.02.08.001--Not Available
Chest pain02.02.02.011; 08.01.08.002; 22.02.08.003--Not Available
Coagulopathy01.01.02.001--Not Available
Coma17.02.09.0010.000036%Not Available
Confusional state17.02.03.005; 19.13.01.0010.000138%
Deafness04.02.01.001--Not Available
Dehydration14.05.05.0010.000138%
Dermatitis23.03.04.002--Not Available
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ADReCS-Target
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