Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Bicalutamide
Drug ID BADD_D00271
Description Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor.
Indications and Usage For treatment (together with surgery or LHRH analogue) of advanced prostatic cancer.
Marketing Status Prescription; Discontinued
ATC Code L02BB03
DrugBank ID DB01128
KEGG ID D00961
MeSH ID C053541
PubChem ID 2375
TTD Drug ID D0V9BD
NDC Product Code 60429-177; 70518-2993; 51846-1028; 16714-816; 62559-680; 0904-6019; 16729-023; 43265-0705; 15308-0360; 54893-0001; 49711-1504; 65841-613; 43265-7195; 49711-1509; 71205-577; 68382-224; 47335-485; 63629-8308; 63759-0004; 62559-890; 53104-7664; 46014-1111; 58623-0068
Synonyms bicalutamide | 4'-cyano-3-(4-fluorophenylsulfonyl)-2-hydroxy-2-methyl-3'-(trifluoromethyl)propionanilide | Casodex | Cosudex | ICI-176334 | ICI 176334
Chemical Information
Molecular Formula C18H14F4N2O4S
CAS Registry Number 90357-06-5
SMILES CC(CS(=O)(=O)C1=CC=C(C=C1)F)(C(=O)NC2=CC(=C(C=C2)C#N)C(F)(F)F)O
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.0020.045111%
Abdominal pain upper07.01.05.003--
Abscess11.01.08.0010.006444%Not Available
Acute hepatic failure09.01.03.0010.005043%Not Available
Acute myeloid leukaemia01.10.05.001; 16.01.05.0010.001681%Not Available
Acute myocardial infarction02.02.02.001; 24.04.04.0010.029000%Not Available
Acute pulmonary oedema02.05.02.004; 22.01.03.0050.001681%Not Available
Acute respiratory distress syndrome22.01.03.0010.002522%
Acute respiratory failure14.01.04.004; 22.02.06.0010.003362%Not Available
Affective disorder19.04.04.0010.012889%Not Available
Agitation17.02.05.012; 19.06.02.001--
Alanine aminotransferase increased13.03.01.0030.041889%
Alopecia23.02.02.001--
Altered state of consciousness17.02.04.001; 19.07.01.0030.009667%Not Available
Anaemia01.03.02.0010.087000%
Anaesthesia17.02.07.0020.003362%Not Available
Anal fistula07.11.05.0020.006444%
Anaphylactic reaction10.01.07.001; 24.06.03.006--
Anaphylactic shock10.01.07.002; 24.06.02.0040.012889%Not Available
Angina pectoris02.02.02.002; 24.04.04.002--
Angina unstable02.02.02.004; 24.04.04.0040.006444%Not Available
Angioedema10.01.05.009; 23.04.01.001--Not Available
Anorectal disorder07.03.01.001--Not Available
Anxiety19.06.02.002--
Aortic aneurysm24.02.03.0010.006444%Not Available
Aphasia17.02.03.001; 19.21.01.0010.009667%
Aphthous ulcer07.05.06.0020.006444%Not Available
Aplastic anaemia01.03.03.0020.001681%Not Available
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