Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Stevens-Johnson syndrome
ADR ID BADD_A04155
ADR Hierarchy
12      Injury, poisoning and procedural complications
12.03      Exposures, chemical injuries and poisoning
12.03.01      Poisoning and toxicity
12.03.01.014      Stevens-Johnson syndrome
23      Skin and subcutaneous tissue disorders
23.03      Epidermal and dermal conditions
23.03.01      Bullous conditions
23.03.01.007      Stevens-Johnson syndrome
10      Immune system disorders
10.01      Allergic conditions
10.01.01      Allergies to foods, food additives, drugs and other chemicals
10.01.01.045      Stevens-Johnson syndrome
11      Infections and infestations
11.07      Ancillary infectious topics
11.07.01      Inflammatory disorders following infection
11.07.01.005      Stevens-Johnson syndrome
Description A disorder characterized by less than 10% total body skin area separation of dermis. The syndrome is thought to be a hypersensitivity complex affecting the skin and the mucous membranes. [CTCAE] Rare cutaneous eruption characterized by extensive KERATINOCYTE apoptosis resulting in skin detachment with mucosal involvement. It is often provoked by the use of drugs (e.g., antibiotics and anticonvulsants) or associated with PNEUMONIA, MYCOPLASMA. It is considered a continuum of Toxic Epidermal Necrolysis. | An exfoliative disease of skin seen primarily in adults and characterized by flaccid bullae and spreading erythema so that the skin has the appearance of being scalded. It results primarily from a toxic reaction to various drugs, but occasionally occurs as a result of infection, neoplastic conditions, or other exposure. [MeSH]
MedDRA Code 10042033
MeSH ID D013262
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Stevens Johnson reaction | Stevens Johnson syndrome | Stevens Johnson type reaction | Stevens Jonhson syndrome | Stevens-Johnson syndrome | Syndrome Stevens-Johnson | Toxic respiratory epitheliolysis | Toxic epitheliolysis | Photoinduced Stevens-Johnson syndrome | Stevens-Johnson Syndrome | Stevens Johnson Syndrome | Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum | Stevens Johnson Syndrome Toxic Epidermal Necrolysis Spectrum | Toxic Epidermal Necrolysis Stevens-Johnson Syndrome Spectrum | Toxic Epidermal Necrolysis Stevens Johnson Syndrome | Toxic Epidermal Necrolysis Stevens Johnson Syndrome Spectrum | Toxic Epidermal Necrolysis Stevens-Johnson Syndrome | Stevens Johnson Syndrome Toxic Epidermal Necrolysis | Stevens-Johnson Syndrome Toxic Epidermal Necrolysis | Mycoplasma-Induced Stevens-Johnson Syndrome | Mycoplasma Induced Stevens Johnson Syndrome | Stevens-Johnson Syndrome, Mycoplasma-Induced | Syndrome, Mycoplasma-Induced Stevens-Johnson | Mycoplasma-Induced Stevens Johnson Syndrome | Drug-Induced Stevens Johnson Syndrome | Drug Induced Stevens Johnson Syndrome | Drug-Induced Stevens-Johnson Syndrome | Drug-Induced Stevens-Johnson Syndromes | Stevens-Johnson Syndrome, Drug-Induced | Stevens-Johnson Syndromes, Drug-Induced | Epidermal Necrolysis, Toxic | Epidermal Necrolyses, Toxic | Necrolyses, Toxic Epidermal | Necrolysis, Toxic Epidermal | Toxic Epidermal Necrolyses | Toxic Epidermal Necrolysis | Scalded Skin Syndrome, Nonstaphylococcal | Lyell's Syndrome | Lyell Syndrome | Lyell's Syndromes | Syndrome, Lyell's | Syndromes, Lyell's | Nonstaphylococcal Scalded Skin Syndrome
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D01814Pralatrexate0.000280%
BADD_D01824Pravastatin--
BADD_D01825Pravastatin sodium--
BADD_D01831Prednisolone0.000157%
BADD_D01834Prednisone0.000036%
BADD_D01835Pregabalin0.000804%
BADD_D01841Probenecid--
BADD_D01858Propagermanium--
BADD_D01867Propranolol--
BADD_D01868Propranolol hydrochloride--
BADD_D01880Pyrazinamide0.001027%
BADD_D01886Pyrimethamine--
BADD_D01888Quetiapine0.000136%
BADD_D01889Quetiapine fumarate--
BADD_D01895Quinine0.001101%
BADD_D01896Quinine dihydrochloride--
BADD_D01897Quinine sulfate--
BADD_D01898Rabeprazole--
BADD_D01899Rabeprazole sodium--
BADD_D01905Raltegravir0.001648%
BADD_D01906Raltegravir potassium--
BADD_D01909Ramipril--
BADD_D01910Ramiprilat--
BADD_D01922Regorafenib0.000504%
BADD_D01924Repaglinide--
BADD_D01933Ribavirin0.051426%
BADD_D01936Rifampicin0.001867%
BADD_D01951Risperidone--
BADD_D01952Ritonavir--
BADD_D01954Rivaroxaban--
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ADReCS-Target
ADR Term Drug Name Target