Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Probenecid
Drug ID BADD_D01841
Description The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
Indications and Usage For the reduction of serum uric acid concentrations in chronic gouty arthritis and tophaceous gout in patients with frequent disabling gout attacks. Has also been effectively used to promote uric acid excretion in hyperuricemia secondary to the administration of thiazide and related diuretics.
Marketing Status approved; investigational
ATC Code M04AB01
DrugBank ID DB01032
KEGG ID D00475
MeSH ID D011339
PubChem ID 4911
TTD Drug ID D0L7FM
NDC Product Code 63415-0026; 0591-5347; 10135-541; 0527-1367; 38779-0345; 43235-0015; 71335-1697; 83008-020; 68022-7061
UNII PO572Z7917
Synonyms Probenecid | Probenecid Weimer | Pro-Cid | Probecid | Benuryl | Benecid | Benemid
Chemical Information
Molecular Formula C13H19NO4S
CAS Registry Number 57-66-9
SMILES CCCN(CCC)S(=O)(=O)C1=CC=C(C=C1)C(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Alopecia23.02.02.001--
Anaemia01.03.02.001--
Anaphylactic reaction10.01.07.001; 24.06.03.006--
Anaphylactic shock10.01.07.002; 24.06.02.004---
Aplastic anaemia01.03.03.002---
Body temperature increased13.15.01.001---
Calculus urinary20.04.03.002---
Dermatitis23.03.04.002---
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.007--
Erythema multiforme10.01.03.015; 23.03.01.003--
Flushing08.01.03.025; 23.06.05.003; 24.03.01.002--
Gingival pain07.09.13.010--
Gouty arthritis14.09.01.004; 15.01.06.004---
Haematuria20.02.01.006; 21.10.01.018; 24.07.01.047--
Haemolytic anaemia01.06.03.002---
Headache17.14.01.001--
Hepatic necrosis09.01.07.002--
Hypersensitivity10.01.03.003--
Leukopenia01.02.02.001---
Nausea07.01.07.001--
Nephrotic syndrome20.05.01.002--
Pain08.01.08.004--
Pollakiuria20.02.02.007--
Pruritus23.03.12.001--
Pyrexia08.05.02.003--
Renal colic20.02.03.010--
Stevens-Johnson syndrome10.01.01.045; 11.07.01.005; 12.03.01.014; 23.03.01.007--
Toxic epidermal necrolysis10.01.01.006; 11.07.01.006; 12.03.01.015; 23.03.01.008--
Urticaria10.01.06.001; 23.04.02.001--
Vomiting07.01.07.003--
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ADReCS-Target
Drug Name ADR Term Target
Tip:  Drug Name  ADR Term  Protein  Variation  Gene