Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Pyrimethamine
Drug ID BADD_D01886
Description One of the folic acid antagonists that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis.
Indications and Usage For the treatment of toxoplasmosis and acute malaria; For the prevention of malaria in areas non-resistant to pyrimethamine
Marketing Status approved; investigational; vet_approved
ATC Code P01BD01
DrugBank ID DB00205
KEGG ID D00488
MeSH ID D011739
PubChem ID 4993
TTD Drug ID D0C0SK
NDC Product Code 63804-5300; 60592-244; 43598-672; 0480-3720; 47781-925; 40074-0008; 59651-564; 68057-001; 57451-1183; 51927-3122; 66651-922; 67763-114; 71052-215; 71554-020; 59651-590; 69413-330; 64677-0006; 71554-028; 72647-330; 51927-0237
UNII Z3614QOX8W
Synonyms Pyrimethamine | Malocide | Tindurine | Chloridin | Daraprim
Chemical Information
Molecular Formula C12H13ClN4
CAS Registry Number 58-14-0
SMILES CCC1=C(C(=NC(=N1)N)N)C2=CC=C(C=C2)Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.0010.000723%-
Abortion spontaneous18.01.04.0010.000142%-
Anaemia megaloblastic01.03.02.003; 14.12.01.003---
Anaphylactic reaction10.01.07.001; 24.06.03.006--
Anaphylactic shock10.01.07.002; 24.06.02.004---
Arrhythmia02.03.02.001---
Cardio-respiratory arrest02.03.04.002; 22.02.06.0070.000283%-
Cerebrovascular accident17.08.01.007; 24.03.05.0010.000142%
Confusional state17.02.03.005; 19.13.01.0010.000482%
Constipation07.02.02.0010.000482%
Cough22.02.03.0010.000312%
Death08.04.01.0010.000425%
Dermatitis exfoliative10.01.01.004; 23.03.07.0010.000142%
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.0070.000312%
Drug interaction08.06.03.0010.000213%-
Dyspnoea02.11.05.003; 22.02.01.0040.000553%
Erythema multiforme10.01.03.015; 23.03.01.003--
Haematuria20.02.01.006; 21.10.01.018; 24.07.01.047--
Headache17.14.01.0010.001204%
Hypersensitivity10.01.03.0030.000793%
Irritability08.01.03.011; 19.04.02.0130.000142%
Leukoencephalopathy17.13.02.0030.000142%
Leukopenia01.02.02.001---
Loss of consciousness17.02.04.0040.000142%-
Malaise08.01.01.0030.000482%
Myocardial ischaemia02.02.02.008; 24.04.04.0100.000354%-
Nausea07.01.07.0010.003344%
Neutropenia01.02.03.0040.000354%-
Pancytopenia01.03.03.003---
Phenylketonuria03.08.04.002; 14.14.04.002; 17.03.07.002; 19.21.06.002; 20.02.01.018---
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