Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Quetiapine fumarate
Drug ID BADD_D01889
Description Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder.[L8546] Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable option for some patients with high sensitivity to other drugs, such as [Clozapine] and [Olanzapine].[A2189]
Indications and Usage For the treatment of schizophrenia and related psychotic disorders.
Marketing Status Prescription; Discontinued
ATC Code N05AH04
DrugBank ID DB01224
KEGG ID D00458
MeSH ID D000069348
PubChem ID 441261
TTD Drug ID D0H7KF
NDC Product Code 67877-249; 71335-0772; 52817-162; 29300-150; 50268-634; 70518-1018; 50090-3342; 68180-613; 63629-4776; 12780-4930; 0904-6642; 59765-145; 65862-493; 70518-2102; 0904-6643; 65015-699; 52817-163; 16571-720; 70518-2522; 14799-1102; 62331-039; 50268-630; 67296-1243; 50742-639; 59765-146; 34908-639; 65862-495; 71335-1519; 55111-190; 51407-068; 68180-449; 16729-097; 65862-494; 68554-0024; 65862-490; 68180-447; 34908-636; 59765-150; 63739-677; 68554-0089; 65862-489; 71610-128; 71610-141; 16729-096; 0781-5344; 55700-941; 69037-0064; 0904-6641; 34908-638; 71610-136; 55111-189; 68001-514; 55111-186; 50268-632; 50090-3198; 16571-717; 70518-2502; 49711-1506; 16364-146; 63187-219; 0781-5343; 33342-104; 50742-638; 68001-511; 51407-074; 13668-153; 61919-911; 70518-2701; 16364-149; 0904-6638; 16571-722; 47335-905; 29300-148; 71335-0926; 29300-149; 68180-445; 29300-147; 50268-631; 47335-907; 70518-0645; 70518-2016; 65862-492; 51407-073; 16436-0061; 0904-6801; 15894-0005; 52817-160; 68071-1892; 16729-109; 16571-721; 47335-903; 70518-2672; 29300-152; 0054-0229; 55111-188; 0781-5346; 52817-161; 46708-863; 51407-076; 67877-246; 52817-164; 47335-902; 71335-1353; 55289-187; 70518-2424; 67877-247; 33342-103; 46708-139; 65096-0106; 71205-031; 59765-147; 70518-2466; 68180-448; 71335-1562; 50090-3983; 67877-250; 0904-6640; 16571-718; 16571-809; 71335-1462; 66651-910; 51407-066; 0904-6805; 50090-3540; 67877-242; 67296-1582; 67877-248; 53747-101; 63629-4964; 68180-446; 55111-053; 55111-249; 50090-3333; 70518-1841; 46708-137; 55111-606; 50090-4022; 43353-008; 70518-1034; 55154-7894; 70518-2752; 33342-100; 65862-491; 0904-6802; 70518-2726; 72189-340; 63629-4841; 59765-149; 59285-024; 68180-450; 50090-5442; 50090-3379; 16729-132; 68069-0006; 71610-127; 0904-6639; 67296-1394; 51407-077; 38779-3081; 43353-957; 47335-906; 77777-114; 59765-148; 13668-148; 0904-6803; 55700-903; 51407-067; 43353-004; 50090-5473; 68788-7960; 68788-9487; 46708-136; 13668-150; 13668-151; 53296-0061; 11712-700; 33342-105; 33342-099; 22365-009; 63187-269; 15308-0320; 67877-245; 70518-2702; 70518-1918; 55289-447; 71335-1362; 73005-0003; 68001-513; 68788-7813; 34908-637; 0054-0221; 46708-135; 62756-628; 51407-075; 70518-2454; 50742-637; 70518-0974; 0904-6804; 51407-071; 76072-1009; 63187-452; 16364-148; 0781-5347; 50090-5884; 68180-612; 63739-665; 71052-653; 0054-0220; 70518-2523; 67296-1336; 50923-0483; 71610-140; 71335-1709; 16364-145; 43353-955; 50090-3303; 52932-0735; 55111-169; 55154-8092; 50742-635; 50268-633; 65372-1114; 50268-635; 33342-101; 50742-636; 16364-147; 65862-262; 70518-3190; 80425-0186; 68001-515; 13668-152; 0781-5342; 68180-615; 51407-069; 63739-690; 0054-0230; 12666-0008; 46708-138; 47335-904; 68788-7950; 29300-151; 16729-095; 0781-5348; 43353-011; 55154-7881; 13668-149; 51407-070; 68180-614; 68788-8065; 66577-033; 46708-134; 48087-0068; 68180-616; 16571-719; 70518-2901; 68001-512; 55289-872; 16364-150; 55154-3359; 50090-3377; 70518-0975; 0781-5345; 60429-416; 80425-0184; 0054-0222; 0054-0223
Synonyms Quetiapine Fumarate | Ethanol, 2-(2-(4-dibenzo(b,f)(1,4)thiazepin-11-yl-1-piperazinyl)ethoxy)-, (E)-2-butenedioate (2:1) (salt) | Seroquel | ICI 204,636 | ICI-204636 | ICI204636 | ICI 204636 | Quetiapine | 2-(2-(4-dibenzo(b,f)(1,4)thiazepine-11-yl-1-piperazinyl)ethoxy)ethanol
Chemical Information
Molecular Formula C46H54N6O8S2
CAS Registry Number 111974-72-2
SMILES C1CN(CCN1CCOCCO)C2=NC3=CC=CC=C3SC4=CC=CC=C42.C1CN(CCN1CCOCCO)C2=NC3=CC=CC=C3SC4= CC=CC=C42.C(=CC(=O)O)C(=O)O
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.002--
Abnormal dreams17.15.02.001; 19.02.03.001--Not Available
Accommodation disorder06.02.04.001--Not Available
Acne23.02.01.001--Not Available
Aggression19.05.01.001--Not Available
Agitation17.02.05.012; 19.06.02.001--
Agranulocytosis01.02.03.001--Not Available
Akathisia17.01.02.002; 19.06.02.006--
Alanine aminotransferase increased13.03.01.003--
Alcohol intolerance14.02.01.001--
Amblyopia06.02.01.001--Not Available
Amenorrhoea05.05.01.002; 21.01.02.001--
Amnesia17.03.02.001; 19.20.01.001--
Anaemia01.03.02.001--
Anaphylactic reaction10.01.07.001; 24.06.03.006--
Angina pectoris02.02.02.002; 24.04.04.002--
Anxiety19.06.02.002--
Apathy19.04.04.002--Not Available
Aphasia17.02.03.001; 19.21.01.001--
Arthralgia15.01.02.001--
Arthritis15.01.01.001--
Arthropathy15.01.01.003--Not Available
Aspartate aminotransferase increased13.03.01.006--
Asthenia08.01.01.001--Not Available
Asthma10.01.03.010; 22.03.01.002--Not Available
Ataxia08.01.02.004; 17.02.02.001--
Atrial fibrillation02.03.03.002--
Atrioventricular block first degree02.03.01.004--
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