Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pralatrexate
Drug ID BADD_D01814
Description Pralatrexate is an antimetabolite for the treatment of relapsed or refractory peripheral T-cell lymphoma. It is more efficiently retained in cancer cells than methotrexate. FDA approved on September 24, 2009.
Indications and Usage Treatment of relapsed or refractory peripheral T-cell lymphoma.
Marketing Status Prescription
ATC Code L01BA05
DrugBank ID DB06813
KEGG ID D05589
MeSH ID C418863
PubChem ID 148121
TTD Drug ID D02LWU
NDC Product Code 72893-003; 48818-001; 47848-045; 68554-0071; 53183-4020; 72893-005; 65392-2510
Synonyms 10-propargyl-10-deazaaminopterin | pralatrexate
Chemical Information
Molecular Formula C23H23N7O5
CAS Registry Number 146464-95-1
SMILES C#CCC(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.0020.000799%
Acute myeloid leukaemia01.10.05.001; 16.01.05.0010.000139%Not Available
Anaemia01.03.02.0010.001598%
Asthenia08.01.01.001--Not Available
Back pain15.03.04.005--
Blood lactate dehydrogenase increased13.04.02.0020.000533%
Body temperature increased13.15.01.001--Not Available
Cardio-respiratory arrest02.03.04.002; 22.02.06.007--Not Available
Constipation07.02.02.001--
Cough22.02.03.001--
Death08.04.01.001--
Dehydration14.05.05.001--
Dermatitis23.03.04.002--Not Available
Dermatitis bullous23.03.01.0020.000533%
Diarrhoea07.02.01.001--
Dyspnoea02.01.03.002; 22.02.01.004--
Epistaxis22.04.03.001; 24.07.01.005--
Erythema multiforme10.01.03.015; 23.03.01.0030.000533%
Fatigue08.01.01.002--
Febrile neutropenia01.02.03.002; 08.05.02.0040.000139%
Gastrointestinal pain07.01.05.005--
Haematemesis07.12.02.002; 24.07.02.0110.000533%Not Available
Hypokalaemia14.05.03.002--
Interstitial lung disease10.02.01.033; 22.01.02.0030.001066%Not Available
Laryngeal pain22.02.05.036--
Leukopenia01.02.02.001--Not Available
Liver disorder09.01.08.0010.000533%Not Available
Liver function test abnormal13.03.01.013--Not Available
Lymphopenia01.02.02.0020.000533%Not Available
Mucosal inflammation08.01.06.0020.001865%Not Available
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