Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Skin hyperpigmentation
ADR ID BADD_A04040
ADR Hierarchy
23      Skin and subcutaneous tissue disorders
23.05      Pigmentation disorders
23.05.01      Hyperpigmentation disorders
23.05.01.003      Skin hyperpigmentation
Description A disorder characterized by darkening of the skin due to excessive melanin deposition. [CTCAE] Excessive pigmentation of the skin, usually as a result of increased epidermal or dermal melanin pigmentation, hypermelanosis. Hyperpigmentation can be localized or generalized. The condition may arise from exposure to light, chemicals or other substances, or from a primary metabolic imbalance. [MeSH]
MedDRA Code 10040865
MeSH ID D017495
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Hyperpigmentation skin | Skin hyperpigmentation | Hypermelanosis | Hyperpigmentation of palms | Palmoplantar hyperpigmentation | Increased skin pigmentation | Periorbital hyperpigmentation | Hyperpigmentation | Hypermelanoses
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D000022-hydroxy-3-phenylpropanoic acid--
BADD_D00033Acetylsalicylic acid0.000022%
BADD_D00048Aflibercept--
BADD_D00052Albendazole0.001691%
BADD_D00075Alitretinoin--
BADD_D00103Amikacin0.000228%
BADD_D00110Aminolevulinic acid--
BADD_D00111Aminolevulinic acid hydrochloride--
BADD_D00121Amlodipine--
BADD_D00129Amoxicillin0.000005%
BADD_D00168Arsenic--
BADD_D00169Arsenic trioxide--
BADD_D00195Azathioprine0.000470%
BADD_D00260Betamethasone--
BADD_D00271Bicalutamide0.001406%
BADD_D00274Bimatoprost0.006926%
BADD_D00277Bisoprolol--
BADD_D00280Bleomycin--
BADD_D00281Bleomycin sulfate--
BADD_D00284Bortezomib0.000246%
BADD_D00294Brimonidine--
BADD_D00318Busulfan--
BADD_D00334Calcipotriene--
BADD_D00349Capecitabine0.003212%
BADD_D00356Carbamazepine0.000465%
BADD_D00364Carboplatin0.000168%
BADD_D00371Carmustine--
BADD_D00445Chlorpromazine--
BADD_D00471Ciprofloxacin--
BADD_D00472Ciprofloxacin hydrochloride--
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ADReCS-Target
ADR Term Drug Name Target