Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Carmustine
Drug ID BADD_D00371
Description A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)
Indications and Usage For the treatment of brain tumors, multiple myeloma, Hodgkin's disease and Non-Hodgkin's lymphomas.
Marketing Status approved; investigational
ATC Code L01AD01
DrugBank ID DB00262
KEGG ID D00254
MeSH ID D002330
PubChem ID 2578
TTD Drug ID D01OXI
NDC Product Code 54879-036; 43598-628; 70710-1525; 70860-223; 0781-3474; 50137-0686; 57821-002; 14593-823; 16729-545; 23155-790; 70121-1482; 76339-121; 50683-0017; 54893-0055; 68475-503; 57884-0032; 16729-548; 23155-649; 55718-139; 59651-168; 24338-050; 58621-002; 59981-034; 23155-261; 71288-126
UNII U68WG3173Y
Synonyms Carmustine | BCNU | N,N'-Bis(2-Chloroethyl)-N-Nitrosourea | FIVB | 1,3-Bis(2-Chloroethyl)-1-Nitrosourea | BiCNU | Nitrumon
Chemical Information
Molecular Formula C5H9Cl2N3O2
CAS Registry Number 154-93-8
SMILES C(CCl)NC(=O)N(CCCl)N=O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Abscess11.01.08.001---
Acute leukaemia01.10.02.001; 16.01.02.001---
Agitation17.02.05.012; 19.06.02.001--
Alopecia23.02.02.001--
Altered state of consciousness17.02.04.001; 19.07.01.0030.000504%-
Amnesia17.03.02.001; 19.20.01.001--
Anaemia01.03.02.001--
Anxiety19.06.02.002--
Aphasia17.02.03.001; 19.21.01.0010.000895%
Arrhythmia02.03.02.001---
Asthenia08.01.01.001---
Ataxia08.01.02.004; 17.02.02.001--
Azotaemia20.01.01.001---
Back pain15.03.04.005--
Blood bilirubin increased13.03.04.018--
Body temperature increased13.15.01.001---
Brain abscess11.01.03.003; 17.06.07.001---
Burning sensation08.01.09.029; 17.02.06.001---
Cerebral haemorrhage17.08.01.003; 24.07.04.0010.000168%-
Cerebral infarction17.08.01.004; 24.04.06.0020.000895%-
Cerebrospinal fluid leakage12.01.10.004; 17.02.05.0010.000392%
Chest pain02.02.02.011; 08.01.08.002; 22.12.02.003---
Coma17.02.09.001---
Condition aggravated08.01.03.0040.001063%-
Confusional state17.02.03.005; 19.13.01.001--
Conjunctival haemorrhage06.07.01.001; 24.07.05.001---
Conjunctival oedema06.04.01.001---
Constipation07.02.02.001--
Coordination abnormal17.02.02.004---
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ADReCS-Target
Drug Name ADR Term Target
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