Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Carboplatin
Drug ID BADD_D00364
Description Carboplatin is an organoplatinum antineoplastic alkylating agent used in the treatment of advanced ovarian carcinoma.[L32253] Early clinical studies of carboplatin were performed in 1982.[A230523] Carboplatin was developed as an analog of [cisplatin] with reduced nephrotoxicity and vomiting.[A230463,A230523] Carboplatin was granted FDA approval on 3 March 1989.[L32248]
Indications and Usage Carboplatin is indicated in combination with an established combination of chemotherapeutic agents for the initial treatment of advanced ovarian carcinoma.[L32253] Carboplatin is also indicated for the palliative treatment of ovarian carcinoma, recurrent after prior chemotherapy.[L32253]
Marketing Status approved
ATC Code L01XA02
DrugBank ID DB00958
KEGG ID D01363
MeSH ID D016190
PubChem ID 426756
TTD Drug ID D0X7HM
NDC Product Code 0703-4239; 55150-386; 63323-172; 68083-191; 63592-0271; 61703-339; 0703-4244; 0703-4246; 72659-863; 50742-447; 69448-005; 61703-600; 55150-334; 61703-262; 61703-360; 71288-100; 49812-0010; 16729-295; 55150-333; 61703-150; 68083-193; 68554-0084; 68083-190; 68083-192; 53104-7570; 54875-0002; 50742-448; 55150-335; 0703-4248
UNII BG3F62OND5
Synonyms Carboplatin | cis-Diammine(cyclobutanedicarboxylato)platinum II | CBDCA | Paraplatin | Paraplatine | Platinwas | Ribocarbo | Carboplat | Neocarbo | Carbosin | Carbotec | Ercar | JM-8 | JM 8 | JM8 | Nealorin | NSC-241240 | NSC 241240 | NSC241240 | Blastocarb
Chemical Information
Molecular Formula C6H12N2O4Pt
CAS Registry Number 41575-94-4
SMILES C1CC(C1)(C(=O)O)C(=O)O.[NH2-].[NH2-].[Pt+2]
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001---
Abdominal pain07.01.05.0020.010185%
Abdominal pain lower07.01.05.010---
Abdominal pain upper07.01.05.0030.003794%
Actinic keratosis23.01.06.0010.000112%-
Acute hepatic failure09.01.03.0010.000280%-
Acute lymphocytic leukaemia01.10.01.001; 16.01.01.0010.000224%-
Acute myeloid leukaemia01.10.05.001; 16.01.05.0010.001119%-
Acute myocardial infarction02.02.02.001; 24.04.04.0010.000728%-
Acute promyelocytic leukaemia01.10.05.003; 16.01.05.0030.000168%-
Acute pulmonary oedema02.05.02.004; 22.01.03.0050.000168%-
Acute respiratory distress syndrome10.02.01.067; 22.01.03.001; 24.03.02.0340.000560%
Acute respiratory failure14.01.04.004; 22.02.06.0010.000728%-
Adenocarcinoma16.16.01.0040.000224%-
Agranulocytosis01.02.03.0010.000728%-
Alopecia23.02.02.0010.005675%
Altered state of consciousness17.02.04.001; 19.07.01.0030.000392%-
Anaemia01.03.02.0010.008831%
Anaphylactic reaction10.01.07.001; 24.06.03.0060.006111%
Anaphylactic shock10.01.07.002; 24.06.02.0040.005652%-
Anaphylactoid reaction10.01.07.003; 24.06.03.0070.000224%-
Angina pectoris02.02.02.002; 24.04.04.0020.000414%
Angioedema10.01.05.009; 22.04.02.008; 23.04.01.0010.001455%-
Anuria20.01.03.0020.000448%-
Apnoea22.02.01.0010.000112%
Arterial thrombosis24.01.01.0020.000280%-
Arteriospasm coronary02.02.02.005; 12.02.01.031; 24.04.04.0050.000112%-
Arthralgia15.01.02.001--
Ascites02.05.04.002; 07.07.01.001; 09.01.05.0030.001175%
Aspartate aminotransferase increased13.03.04.011--
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ADReCS-Target
Drug Name ADR Term Target
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