Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Hypotonia
ADR ID BADD_A02223
ADR Hierarchy
17      Nervous system disorders
17.05      Neuromuscular disorders
17.05.02      Muscle tone abnormal
17.05.02.002      Hypotonia
15      Musculoskeletal and connective tissue disorders
15.05      Muscle disorders
15.05.04      Muscle tone abnormalities
15.05.04.008      Hypotonia
Description A diminution of the skeletal muscle tone marked by a diminished resistance to passive stretching. [MeSH]
MedDRA Code 10021118
MeSH ID D009123; D009126
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Abdominal flaccidity | Atonia | Atony skeletal muscle | Decreased muscle tone | Flaccidity | Flaccidity muscle | Floppy | Hypotonia | M relaxation | Muscle flaccid | Muscle relaxation | Muscle tone decreased | Muscle tone flaccid | Non-depolarising relaxant | Skeletal muscle atony | Generalized atony | Generalised atony | Muscle hypotonia | Muscle Hypotonia | Hypotonia, Muscle | Decreased Muscle Tone | Muscle Tone, Decreased | Muscle Tone Poor | Tone Poor, Muscle | Hypotony, Muscle | Muscle Hypotony | Muscular Hypotonia | Hypotonia, Muscular | Hypomyotonia | Unilateral Hypotonia | Hypotonia, Unilateral | Hypotonias, Unilateral | Muscle Tone Atonic | Muscle Tone Atonics | Tone Atonic, Muscle | Neonatal Hypotonia | Hypotonia, Neonatal | Hypotonias, Neonatal | Neonatal Hypotonias | Flaccid Muscle Tone | Muscle Tone, Flaccid | Muscular Flaccidity | Flaccidity, Muscular | Muscular Flaccidities | Muscle Flaccidity | Flaccidity, Muscle | Floppy Muscles | Floppy Muscle | Muscle, Floppy | Muscles, Floppy
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D01867Propranolol0.000401%
BADD_D01881Pyridostigmine0.002125%
BADD_D01888Quetiapine0.000164%
BADD_D01909Ramipril0.000420%
BADD_D01915Ranolazine0.000284%
BADD_D01942Riluzole--
BADD_D01951Risperidone0.000849%
BADD_D01959Rocuronium0.000085%
BADD_D01966Ropinirole--
BADD_D01968Ropivacaine hydrochloride--
BADD_D01969Ropivacaine hydrochloride monohydrate--
BADD_D01971Rosuvastatin0.000026%
BADD_D01996Sebelipase alfa--
BADD_D02002Selegiline--
BADD_D02010Sertraline0.000089%
BADD_D02011Sertraline hydrochloride--
BADD_D02026Simvastatin0.000029%
BADD_D02028Sirolimus--
BADD_D02069Stiripentol--
BADD_D02079Succinylcholine--
BADD_D02080Succinylcholine chloride--
BADD_D02083Sufentanil citrate--
BADD_D02175Tetrabenazine0.000808%
BADD_D02197Thiamine0.001421%
BADD_D02210Tiagabine--
BADD_D02211Tiagabine hydrochloride--
BADD_D02222Tinzaparin sodium--
BADD_D02247Topiramate0.000226%
BADD_D02254Tramadol0.000043%
BADD_D02268Treprostinil0.000123%
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