Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Succinylcholine chloride
Drug ID BADD_D02080
Description Succinylcholine is a depolarizing skeletal muscle relaxant consisting of two molecules of the endogenous neurotransmitter [acetylcholine] (ACh) linked by their acetyl groups.[A19054] It has been widely used for over 50 years,[A299] most commonly in its chloride salt form, as a means of neuromuscular blockade during intubation and surgical procedures. Its rapid onset and offset, with effects beginning within 60 seconds of intravenous administration and lasting between four to six minutes, make succinylcholine particularly useful in the setting of short medical procedures requiring brief periods of muscle relaxation.[L9004]
Indications and Usage Succinylcholine is indicated as an adjunct to general anesthesia, to facilitate tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation.[L9004]
Marketing Status approved
ATC Code M03AB01
DrugBank ID DB00202
KEGG ID D00766
MeSH ID D013390
PubChem ID 22475
TTD Drug ID D0Q7ZQ
NDC Product Code 0641-6234; 11712-832; 70069-783; 71872-7166; 71872-7275; 0781-9053; 51662-1526; 71288-719; 71872-7026; 69918-700; 70121-1581; 70710-1377; 70756-613; 71872-7146; 68083-450; 71872-7272; 75834-151; 49452-7395; 70069-301; 70771-1352; 72572-750; 25021-677; 0143-9338; 71872-7167; 71872-7279; 54879-037; 63323-943; 71872-7221; 16729-493; 42571-371; 66794-232; 0409-6629; 71872-7251; 71872-7263; 66064-1028; 72643-002; 31722-981; 62512-0068; 14445-407; 0404-9983; 0781-3411; 11712-830; 14789-104; 51662-1353; 51662-1525
UNII I9L0DDD30I
Synonyms Succinylcholine | Succinyldicholine | Suxamethonium | Dicholine Succinate | Succinate, Dicholine | Quelicin | Succinylcholine Dichloride | Dichloride, Succinylcholine | Succinylcholine Dichloride, Di-H2O | Succinylcholine Dichloride, Di H2O | Succinylcholine Diiodide | Diiodide, Succinylcholine | Myorelaxin | Succinylcholine Diperchlorate | Diperchlorate, Succinylcholine | Succinylcholine Iodide | Suxamethonium Bromide | Bromide, Suxamethonium | Suxamethonium Chloride | Listenon | Succinylcholine Chloride | Anectine | Celocurine | Ditilin | Lysthenon | Succicuran | Succinylcholine Dibromide | Dibromide, Succinylcholine
Chemical Information
Molecular Formula C14H30N2O4.2Cl
CAS Registry Number 71-27-2
SMILES C[N+](C)(C)CCOC(=O)CCC(=O)OCC[N+](C)(C)C.[Cl-].[Cl-]
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Anaphylactic reaction10.01.07.001; 24.06.03.006--
Anaphylactoid reaction10.01.07.003; 24.06.03.007---
Apnoea22.02.01.001--
Arrhythmia02.03.02.001---
Bradycardia02.03.02.002---
Cardiac arrest02.03.04.001--
Hyperkalaemia14.05.03.001--
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Hyperthermia malignant08.05.01.002---
Hypotension24.06.03.002--
Hypotonia15.05.04.008; 17.05.02.002---
Intracranial pressure increased17.07.02.002---
Muscle contractions involuntary15.05.03.008; 17.05.03.001---
Rash23.03.13.001---
Respiratory depression17.02.05.047; 22.02.01.010---
Rhabdomyolysis15.05.05.002--
Salivary hypersecretion07.06.01.009---
Tachycardia02.03.02.007---
Jaw disorder15.02.04.009---
Procedural pain08.01.08.009; 12.02.05.007---
Acute kidney injury20.01.03.016--
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