Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Extrapyramidal disorder
ADR ID BADD_A01568
ADR Hierarchy
17      Nervous system disorders
17.01      Movement disorders (incl parkinsonism)
17.01.02      Dyskinesias and movement disorders NEC
17.01.02.007      Extrapyramidal disorder
Description A disorder characterized by abnormal, repetitive, involuntary muscle movements, frenzied speech and extreme restlessness. [CTCAE] Diseases of the BASAL GANGLIA including the PUTAMEN; GLOBUS PALLIDUS; claustrum; AMYGDALA; and CAUDATE NUCLEUS. DYSKINESIAS (most notably involuntary movements and alterations of the rate of movement) represent the primary clinical manifestations of these disorders. Common etiologies include CEREBROVASCULAR DISORDERS; NEURODEGENERATIVE DISEASES; and CRANIOCEREBRAL TRAUMA. [MeSH]
MedDRA Code 10015832
MeSH ID D001480
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Benign shuddering attacks | Drug-induced extrapyramidal side effects | Extrapyramidal disorder | Extrapyramidal disorder (NOS) | Extrapyramidal disorder NEC | Extrapyramidal symptoms | Extrapyramidal syndrome | Extrapyramidal syndrome (NOS) | Other and unspecified extrapyramidal diseases and abnormal movement disorders | Other extrapyramidal disease and abnormal movement disorders | Other extrapyramidal diseases and abnormal movement disorders | Syndrome extrapyramidal | Unspecified extrapyramidal disease and abnormal movement disorder | Extrapyramidal disorder aggravate | Extrapyramidal disorder aggravated | Basal Ganglia Diseases | Basal Ganglia Disease | Basal Ganglia Disorders | Basal Ganglia Disorder | Extrapyramidal Disorders | Extrapyramidal Disorder | Lenticulostriate Disorders | Lenticulostriate Disorder
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00062Aldesleukin--
BADD_D00085Alprazolam0.000107%
BADD_D00115Amiodarone--
BADD_D00116Amiodarone hydrochloride--
BADD_D00117Amisulpride0.000131%
BADD_D00118Amitriptyline--
BADD_D00119Amitriptyline hydrochloride--
BADD_D00125Ammonium lactate--
BADD_D00128Amoxapine--
BADD_D00165Aripiprazole0.005524%
BADD_D00166Aripiprazole lauroxil-
BADD_D00172Asenapine0.005254%
BADD_D00173Asenapine maleate--
BADD_D00244Benztropine--
BADD_D00293Brexpiprazole0.003659%
BADD_D00312Bupropion--
BADD_D00313Bupropion hydrobromide--
BADD_D00314Bupropion hydrochloride--
BADD_D00316Buspirone--
BADD_D00317Buspirone hydrochloride--
BADD_D00356Carbamazepine--
BADD_D00359Carbidopa--
BADD_D00369Cariprazine0.004952%
BADD_D00417Cetirizine0.000029%
BADD_D00432Chlordiazepoxide--
BADD_D00433Chlordiazepoxide hydrochloride--
BADD_D00440Chloroquine--
BADD_D00445Chlorpromazine0.001490%
BADD_D00446Chlorpromazine hydrochloride--
BADD_D00475Citalopram--
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ADReCS-Target
ADR Term Drug Name Target