Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Chlorpromazine hydrochloride
Drug ID BADD_D00446
Description The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
Indications and Usage For the treatment of schizophrenia; to control nausea and vomiting; for relief of restlessness and apprehension before surgery; for acute intermittent porphyria; as an adjunct in the treatment of tetanus; to control the manifestations of the manic type of manic-depressive illness; for relief of intractable hiccups; for the treatment of severe behavioral problems in children (1 to 12 years of age) marked by combativeness and/or explosive hyperexcitable behavior (out of proportion to immediate provocations), and in the short-term treatment of hyperactive children who show excessive motor activity with accompanying conduct disorders consisting of some or all of the following symptoms: impulsivity, difficulty sustaining attention, aggressivity, mood lability, and poor frustration tolerance.
Marketing Status approved; investigational; vet_approved
ATC Code N05AA01
DrugBank ID DB00477
KEGG ID D00789
MeSH ID D002746
PubChem ID 6240
TTD Drug ID D01ZII
NDC Product Code 0781-4028; 0832-6021; 0904-7131; 23155-806; 50268-164; 50268-166; 60687-419; 60687-430; 64950-240; 64950-241; 69238-1054; 69238-1062; 70518-0016; 0527-2965; 70518-3086; 70518-3584; 70771-1509; 72205-104; 0832-0302; 90096-134; 58793-013; 71554-002; 73435-001; 16714-051; 23155-803; 51407-437; 60687-452; 62135-421; 0404-9836; 70518-3348; 70710-1130; 72205-105; 0641-1397; 0832-0300; 0832-0304; 90096-135; 71666-006; 23155-804; 24338-410; 50090-5965; 50268-162; 53808-1104; 55150-319; 68462-863; 69238-1056; 0527-2962; 70518-3590; 70518-3670; 70518-3674; 70710-1132; 69238-1058; 70518-3280; 70771-1510; 72205-107; 0832-6018; 0832-6019; 0832-6020; 51552-0139; 67763-115; 24338-403; 52584-397; 62135-420; 62135-424; 68462-865; 0527-2964; 70518-3321; 70710-1131; 0641-1398; 0832-6017; 90096-131; 0904-7132; 38779-0423; 23155-805; 23155-807; 50268-163; 50268-165; 70518-3435; 70518-3510; 70518-3549; 70710-1133; 0832-0301; 0904-7130; 0904-7133; 62991-1425; 16714-047; 16714-049; 51407-435; 51407-438; 62135-423; 68462-864; 70518-3034; 70710-1129; 70771-1506; 70966-0017; 82298-901; 50090-6029; 51407-434; 55150-318; 70518-3673; 0832-0303; 0904-7129; 16714-050; 62135-422; 68462-861; 0527-2961; 70771-1508; 0781-4027; 90096-133; 42413-0137; 16714-048; 60687-441; 60687-463; 68462-862; 69238-1060; 0527-2963; 70771-1507; 72205-106; 90096-132; 72166-004; 51407-436
UNII 9WP59609J6
Synonyms Chlorpromazine | Thorazine | Aminazine | Largactil | Chlordelazine | Chlorpromazine Hydrochloride | Hydrochloride, Chlorpromazine | Contomin | Fenactil | Propaphenin | Chlorazine
Chemical Information
Molecular Formula C17H19ClN2S.ClH
CAS Registry Number 69-09-0
SMILES CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl.Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Agranulocytosis01.02.03.001---
Akathisia17.01.02.002; 19.06.02.006--
Amenorrhoea05.05.01.002; 21.01.02.001--
Anaphylactoid reaction10.01.07.003; 24.06.03.007---
Angioedema10.01.05.009; 22.04.02.008; 23.04.01.001---
Aplastic anaemia01.03.03.002---
Asthma10.01.03.010; 22.03.01.002---
Breast engorgement18.08.02.001; 21.05.05.002---
Constipation07.02.02.001--
CSF protein abnormal13.07.02.004---
Dermatitis contact10.01.01.003; 12.03.01.040; 23.03.04.004---
Dermatitis exfoliative10.01.01.004; 23.03.07.001--
Dry mouth07.06.01.002--
Dystonia17.01.03.001---
Ejaculation disorder21.03.01.002--
Eosinophilia01.02.04.001--
Extrapyramidal disorder17.01.02.007--
Eye disorder06.08.03.001---
Glycosuria20.02.01.005--
Gynaecomastia05.05.02.003; 21.05.04.003--
Haemolytic anaemia01.06.03.002---
Hyperglycaemia05.06.02.002; 14.06.02.002--
Hyperpyrexia08.05.02.002---
Hypersensitivity10.01.03.003--
Hypoglycaemia05.06.03.001; 14.06.03.001--
Hypotension24.06.03.002--
Ileus paralytic07.02.05.001---
Increased appetite08.01.09.027; 14.03.01.003---
Jaundice01.06.04.004; 09.01.01.004; 23.03.03.030---
Laryngeal oedema10.01.05.003; 22.04.02.001; 23.04.01.005--
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