Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Brain hypoxia
ADR ID BADD_A00666
ADR Hierarchy
17      Nervous system disorders
17.08      Central nervous system vascular disorders
17.08.02      Central nervous system vascular disorders NEC
17.08.02.009      Brain hypoxia
24      Vascular disorders
24.04      Arteriosclerosis, stenosis, vascular insufficiency and necrosis
24.04.06      Cerebrovascular and spinal necrosis and vascular insufficiency
24.04.06.022      Brain hypoxia
22      Respiratory, thoracic and mediastinal disorders
22.02      Respiratory disorders NEC
22.02.02      Conditions associated with abnormal gas exchange
22.02.02.010      Brain hypoxia
Description A reduction in brain oxygen supply due to ANOXEMIA (a reduced amount of oxygen being carried in the blood by HEMOGLOBIN), or to a restriction of the blood supply to the brain, or both. Severe hypoxia is referred to as anoxia, and is a relatively common cause of injury to the central nervous system. Prolonged brain anoxia may lead to BRAIN DEATH or a PERSISTENT VEGETATIVE STATE. Histologically, this condition is characterized by neuronal loss which is most prominent in the HIPPOCAMPUS; GLOBUS PALLIDUS; CEREBELLUM; and inferior olives. [MeSH]
MedDRA Code 10006127
MeSH ID D002534
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Anoxia cerebral | Brain hypoxia | Hypoxia, Brain | Cerebral Hypoxia | Hypoxia, Cerebral | Brain Hypoxia | Anoxic Brain Damage | Brain Damage, Anoxic | Damage, Anoxic Brain | Anoxic Encephalopathy | Anoxic Encephalopathies | Encephalopathies, Anoxic | Encephalopathy, Anoxic | Hypoxic Brain Damage | Brain Damage, Hypoxic | Damage, Hypoxic Brain | Hypoxic Encephalopathy | Encephalopathy, Hypoxic | Encephalopathies, Hypoxic | Hypoxic Encephalopathies | Anoxia, Brain | Cerebral Anoxia | Anoxia, Cerebral | Brain Anoxia
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00085Alprazolam0.000072%
BADD_D00151Apixaban0.000043%
BADD_D00332Caffeine--
BADD_D00407Cefuroxime0.000286%
BADD_D00511Clozapine0.003669%
BADD_D00551Cyclosporine--
BADD_D00768Enalaprilat0.002026%
BADD_D01387Mepivacaine--
BADD_D01388Mepivacaine hydrochloride--
BADD_D01498Morphine0.000278%
BADD_D01645Oxycodone0.000041%
BADD_D01836Prilocaine--
BADD_D01888Quetiapine0.000055%
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