ADReCS

Pharmaceutical Information

Drug Name	Cefuroxime
Drug ID	BADD_D00407
Description	Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, gonorrhea, and haemophilus.
Indications and Usage	For the treatment of many different types of bacterial infections such as bronchitis, sinusitis, tonsillitis, ear infections, skin infections, gonorrhea, and urinary tract infections.
Marketing Status	approved
ATC Code	J01DC02; S01AA27
DrugBank ID	DB01112
KEGG ID	D00262
MeSH ID	D002444
PubChem ID	41375
TTD Drug ID	D0Y2IE
NDC Product Code	0143-9567; 0143-9569; 0143-9976; 0143-9568; 0143-9977; 0143-9979
UNII	O1R9FJ93ED
Synonyms	Cefuroxime \| Cephuroxime \| Zinacef \| Ketocef

Chemical Information

Molecular Formula	C16H16N4O8S
CAS Registry Number	55268-75-2
SMILES	CON=C(C1=CC=CO1)C(=O)NC2C3N(C2=O)C(=C(CS3)COC(=O)N)C(=O)O
Chemical Structure

ADRs Induced by Drug

*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Abdominal distension	07.01.04.001	0.000773%
Abdominal pain	07.01.05.002	0.001660%
Abdominal pain lower	07.01.05.010	-	-	-
Abdominal tenderness	07.01.05.004	0.000143%		-
Acute respiratory distress syndrome	10.02.01.067; 22.01.03.001; 24.03.02.034	0.000143%
Agitation	17.02.05.012; 19.06.02.001	-	-
Agitation neonatal	17.02.05.028; 18.04.04.002	0.000143%		-
Agranulocytosis	01.02.03.001	0.000429%		-
Alanine aminotransferase increased	13.03.04.005	-	-
Alcohol intolerance	14.02.01.001	0.000358%
Altered state of consciousness	17.02.04.001; 19.07.01.003	0.000215%		-
Anaphylactic reaction	10.01.07.001; 24.06.03.006	0.006653%
Anaphylactic shock	10.01.07.002; 24.06.02.004	0.004221%		-
Anaphylactoid reaction	10.01.07.003; 24.06.03.007	0.000501%		-
Angioedema	10.01.05.009; 22.04.02.008; 23.04.01.001	0.002504%		-
Anosmia	17.04.04.001; 22.04.03.006	0.000143%
Aplastic anaemia	01.03.03.002	-	-	-
Arteriosclerosis coronary artery	02.02.01.011; 24.04.04.012	0.000215%		-
Arteriospasm coronary	02.02.02.005; 12.02.01.031; 24.04.04.005	0.000429%		-
Arthralgia	15.01.02.001	-	-
Aspartate aminotransferase increased	13.03.04.011	-	-
Asphyxia	12.01.08.011; 22.02.02.001	0.000143%		-
Auditory disorder	04.02.03.002	0.000143%		-
Back pain	15.03.04.005	0.001574%
Blindness	06.02.10.003; 17.17.01.003	0.000715%		-
Blister	12.01.06.002; 23.03.01.001	0.000916%		-
Blood bilirubin increased	13.03.04.018	-	-
Blood creatinine decreased	13.13.01.003	-	-	-
Blood creatinine increased	13.13.01.004	-	-
Blood lactate dehydrogenase increased	13.04.02.002	-	-

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