Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Morphine
Drug ID BADD_D01498
Description Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805.[A176035] It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse.[A176050] Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [fentanyl], [methadone], [hydrocodone], [hydromorphone], [meperidine], and [oxycodone]. Morphine was granted FDA approval in 1941.[L12114]
Indications and Usage For the relief and treatment of severe pain.
Marketing Status Prescription; Discontinued
ATC Code N02AA01
DrugBank ID DB00295
KEGG ID D08233
MeSH ID D009020
PubChem ID 5288826
TTD Drug ID D0WE3O
NDC Product Code 42799-217
Synonyms Morphine | Morphia | Morphine Chloride | Chloride, Morphine | Morphine Sulfate | Sulfate, Morphine | SDZ 202-250 | SDZ 202 250 | SDZ 202250 | SDZ202-250 | SDZ202 250 | SDZ202250 | Morphine Sulfate (2:1), Pentahydrate | MS Contin | Contin, MS | Oramorph SR | Duramorph | Morphine Sulfate (2:1), Anhydrous
Chemical Information
Molecular Formula C17H19NO3
CAS Registry Number 57-27-2
SMILES CN1CCC23C4C1CC5=C2C(=C(C=C5)O)OC3C(C=C4)O
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.003--
Abnormal dreams17.15.02.001; 19.02.03.001--Not Available
Abscess11.01.08.001--Not Available
Accidental overdose12.06.03.002--Not Available
Acidosis14.01.03.0020.000703%
Acute myocardial infarction02.02.02.001; 24.04.04.001--Not Available
Acute respiratory distress syndrome22.01.03.0010.001222%
Acute respiratory failure14.01.04.004; 22.02.06.001--Not Available
Addison's disease05.01.02.006; 10.04.08.008; 14.11.01.025--Not Available
Adrenal insufficiency05.01.02.001; 14.11.01.0040.001406%
Aggression19.05.01.001--Not Available
Agitation17.02.05.012; 19.06.02.0010.013824%
Alanine aminotransferase increased13.03.01.003--
Alcohol abuse19.07.02.0070.000122%Not Available
Alcoholism19.07.02.001--Not Available
Altered state of consciousness17.02.04.001; 19.07.01.0030.003749%Not Available
Amblyopia06.02.01.001--Not Available
Amenorrhoea05.05.01.002; 21.01.02.001--
Amnesia17.03.02.001; 19.20.01.001--
Anaemia01.03.02.001--
Anaesthesia17.02.07.0020.000703%Not Available
Anaesthetic complication pulmonary12.02.12.007; 22.02.07.0050.000703%Not Available
Anaphylactic reaction10.01.07.001; 24.06.03.0060.020150%
Anaphylactic shock10.01.07.002; 24.06.02.0040.002109%Not Available
Anaphylactoid reaction10.01.07.003; 24.06.03.007--Not Available
Angina pectoris02.02.02.002; 24.04.04.002--
Angioedema10.01.05.009; 23.04.01.001--Not Available
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ADReCS-Target
Drug Name ADR Term Target
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