Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Adrenal insufficiency
ADR ID BADD_A00108
ADR Hierarchy
14      Metabolism and nutrition disorders
14.11      Metabolism disorders NEC
14.11.01      Metabolic disorders NEC
14.11.01.004      Adrenal insufficiency
05      Endocrine disorders
05.01      Adrenal gland disorders
05.01.02      Adrenal cortical hypofunctions
05.01.02.001      Adrenal insufficiency
Description A disorder characterized by the adrenal cortex not producing enough of the hormone cortisol and in some cases, the hormone aldosterone. It may be due to a disorder of the adrenal cortex as in Addison's disease or primary adrenal insufficiency. [CTCAE] Conditions in which the production of adrenal CORTICOSTEROIDS falls below the requirement of the body. Adrenal insufficiency can be caused by defects in the ADRENAL GLANDS, the PITUITARY GLAND, or the HYPOTHALAMUS. [MeSH]
MedDRA Code 10001367
MeSH ID D000309
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Adrenal cortex hypofunction | Adrenal cortex insufficiency | Adrenal cortex insuffiency | Adrenal cortical hypofunction | Adrenal cortical insufficiency | Adrenal hypofunction | Adrenal insufficiency | Adrenal insufficiency NOS | Corticoadrenal insufficiency | Hypoadrenalism | Hypofunction adrenal | Insufficiency adrenal | Insufficiency adrenal cortex | Other adrenal hypofunction | Hypoadrenocorticism | Adrenal gland insufficiency | Adrenal Insufficiency | Adrenal Insufficiencies | Adrenal Gland Hypofunction | Hypofunction, Adrenal Gland
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00912Fluconazole0.000180%
BADD_D00914Fludarabine0.000112%
BADD_D00932Fluoxetine0.000069%
BADD_D00946Fluticasone furoate0.000917%
BADD_D00947Fluticasone propionate0.001659%
BADD_D01086Hydrocortisone0.000115%
BADD_D01119Ibrutinib0.000224%
BADD_D01120Ibuprofen--
BADD_D01121Ibuprofen lysine--
BADD_D01156Indomethacin--
BADD_D01190Ipilimumab--
BADD_D01217Itraconazole0.008017%
BADD_D01230Ketoconazole0.000330%
BADD_D01254Lenvatinib0.000336%
BADD_D01275Levofloxacin0.000042%
BADD_D01285Levothyroxine0.000025%
BADD_D01300Lisinopril0.000009%
BADD_D01366Medroxyprogesterone acetate0.000119%
BADD_D01371Megestrol--
BADD_D01372Megestrol acetate0.004151%
BADD_D01405Methadone0.000928%
BADD_D01433Methylprednisolone0.000192%
BADD_D01450Metyrapone0.000148%
BADD_D01463Mifepristone0.000485%
BADD_D01479Mitotane0.000280%
BADD_D01491Mometasone furoate0.001486%
BADD_D01496Montelukast0.000015%
BADD_D01506Muromonab-cd3--
BADD_D01595Octreotide acetate--
BADD_D01645Oxycodone--
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