Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Mitotane
Drug ID BADD_D01479
Description A derivative of the insecticide dichlorodiphenyldichloroethane that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.
Indications and Usage For treatment of inoperable adrenocortical tumours; Cushing's syndrome
Marketing Status approved
ATC Code L01XX23
DrugBank ID DB00648
KEGG ID D00420
MeSH ID D008939
PubChem ID 4211
TTD Drug ID D0Z5OE
NDC Product Code 71052-048; 76336-080; 62991-2604; 14799-2009; 38779-2263; 21222-002; 49452-4786
UNII 78E4J5IB5J
Synonyms Mitotane | o,p-DDD | Mytotan | ortho,para-DDD | ortho,para DDD | Chlodithane | Lysodren | Chloditan | Khloditan
Chemical Information
Molecular Formula C14H10Cl4
CAS Registry Number 53-19-0
SMILES C1=CC=C(C(=C1)C(C2=CC=C(C=C2)Cl)C(Cl)Cl)Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Adrenal insufficiency05.01.02.001; 14.11.01.0040.000280%
Aggression19.05.01.001---
Albuminuria20.02.01.001---
Amenorrhoea05.05.01.002; 21.01.02.0010.000168%
Amnesia17.03.02.001; 19.20.01.001--
Anaemia01.03.02.001--
Asthenia08.01.01.0010.000168%-
Ataxia08.01.02.004; 17.02.02.001--
Autoimmune hepatitis09.01.07.019; 10.04.09.001---
Bleeding time prolonged13.01.02.002---
Blood cholesterol increased13.12.01.002--
Blood triglycerides increased13.12.03.001---
Blood uric acid decreased13.02.04.004---
Body temperature increased13.15.01.001---
Burning sensation08.01.09.029; 17.02.06.0010.000112%-
Cataract06.06.01.001--
Confusional state17.02.03.005; 19.13.01.001--
Cystitis haemorrhagic20.03.02.003---
Death08.04.01.0010.000504%
Depression19.15.01.0010.000246%
Dermatitis23.03.04.002---
Dermatitis allergic10.01.03.014; 23.03.04.003---
Dermatitis atopic10.01.04.004; 23.03.04.016---
Diarrhoea07.02.01.0010.000302%
Diplopia06.02.06.002; 17.17.01.005---
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.0070.000548%
Dysarthria17.02.08.001; 19.19.03.001--
Dysgeusia07.14.03.001; 17.02.07.003--
Dyskinesia17.01.02.006--
Dyspepsia07.01.02.001--
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