Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Fludarabine
Drug ID BADD_D00914
Description Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara.
Indications and Usage For the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to or whose disease has progressed during treatment with at least one standard alkylating-agent containing regimen
Marketing Status Not Available
ATC Code L01BB05
DrugBank ID DB01073
KEGG ID D07966
MeSH ID C024352
PubChem ID 657237
TTD Drug ID D0F2XQ
NDC Product Code Not Available
Synonyms fludarabine | 9H-purin-6-amine, 9-beta-D-arabinofuranosyl-2-fluoro- | F-ara-A | 2-fluoroadenine arabinoside | 9-beta-D-arabinofuranosyl-2-fluoroadenine
Chemical Information
Molecular Formula C10H12FN5O4
CAS Registry Number 21679-14-1
SMILES C1=NC2=C(N=C(N=C2N1C3C(C(C(O3)CO)O)O)F)N
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.003--
Acute leukaemia01.10.02.001; 16.01.02.001--Not Available
Acute myeloid leukaemia01.10.05.001; 16.01.05.0010.001459%Not Available
Acute respiratory distress syndrome22.01.03.0010.000208%
Agitation17.02.05.012; 19.06.02.0010.001332%
Alopecia23.02.02.001--
Alveolitis allergic10.01.03.008; 22.01.01.002--Not Available
Anaemia01.03.02.001--
Anaphylactic shock10.01.07.002; 24.06.02.004--Not Available
Aneurysm24.02.01.001--Not Available
Angina pectoris02.02.02.002; 24.04.04.0020.000533%
Angioimmunoblastic T-cell lymphoma01.11.05.001; 16.17.05.0010.000533%Not Available
Anxiety19.06.02.002--
Aplasia03.02.01.002; 08.03.04.003--Not Available
Aplasia pure red cell01.03.03.001; 10.02.01.0030.000533%Not Available
Apnoea22.02.01.0010.000533%
Arrhythmia02.03.02.001--Not Available
Arthralgia15.01.02.001--
Asthenia08.01.01.001--Not Available
Back pain15.03.04.005--
Bacteraemia11.01.11.0010.000533%
Basal cell carcinoma16.03.02.001; 23.08.02.0010.000533%Not Available
Blindness06.02.02.001; 17.17.01.0030.000799%Not Available
Blood lactate dehydrogenase increased13.04.02.0020.000533%
Blood uric acid increased13.02.04.001--Not Available
Body temperature increased13.15.01.0010.000533%Not Available
Bone pain15.02.01.0010.000799%
Breast cancer16.10.01.001; 21.05.01.0030.000533%Not Available
Bronchiolitis11.05.04.008; 22.03.02.0040.000533%Not Available
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