Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Metyrapone
Drug ID BADD_D01450
Description An inhibitor of the enzyme steroid 11-beta-monooxygenase. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of cushing syndrome.
Indications and Usage Used as a diagnostic drug for testing hypothalamic-pituitary ACTH function. Occasionally used in Cushing's syndrome.
Marketing Status approved; investigational
ATC Code V04CD01
DrugBank ID DB01011
KEGG ID D00410
MeSH ID D008797
PubChem ID 4174
TTD Drug ID D0Q9JT
NDC Product Code 70219-0001; 55361-0011; 76336-455
UNII ZS9KD92H6V
Synonyms Metyrapone | Methbipyranone | Methopyrapone | SU 4885 | Metopirone | Métopirone | Metopiron
Chemical Information
Molecular Formula C14H14N2O
CAS Registry Number 54-36-4
SMILES CC(C)(C1=CN=CC=C1)C(=O)C2=CN=CC=C2
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001---
Abdominal pain07.01.05.002--
Abortion spontaneous18.01.04.0010.000099%-
Adrenal insufficiency05.01.02.001; 14.11.01.0040.000148%
Adrenocortical insufficiency acute05.01.02.005; 14.11.01.0200.000099%-
Alopecia23.02.02.001--
Anaemia01.03.02.0010.000099%
Dermatitis allergic10.01.03.014; 23.03.04.003---
Dermatitis atopic10.01.04.004; 23.03.04.016---
Diarrhoea07.02.01.0010.000099%
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.007--
Dysphagia07.01.06.0030.000099%
Dyspnoea02.11.05.003; 22.02.01.0040.000099%
Endocrine disorder05.09.01.001---
Gastrointestinal disorder07.11.01.001---
Gastrointestinal pain07.01.05.005--
Headache17.14.01.001--
Hirsutism05.05.01.005; 23.02.04.001--
Hypercalcaemia05.04.01.002; 14.04.01.0030.000099%
Hypertension24.08.02.001--
Hypotension24.06.03.0020.000198%
Malaise08.01.01.0030.000217%
Nausea07.01.07.0010.000099%
Nervous system disorder17.02.10.001---
Oedema peripheral02.05.04.007; 08.01.07.007; 14.05.06.0110.000099%
Pain08.01.08.004--
Pancytopenia01.03.03.003---
Premature baby18.04.02.0010.000099%-
Premature delivery18.07.01.0060.000099%
Pulmonary embolism22.06.02.001; 24.01.06.0010.000148%-
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