Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Clozapine
Drug ID BADD_D00511
Description A tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
Indications and Usage For use in patients with treatment-resistant schizophrenia.
Marketing Status approved
ATC Code N05AH02
DrugBank ID DB00363
KEGG ID D00283
MeSH ID D003024
PubChem ID 135398737
TTD Drug ID D0Z1RV
NDC Product Code 73377-150; 51079-288; 51079-749; 51407-085; 63629-2359; 0378-3813; 65862-846; 63552-062; 64374-004; 76072-1010; 16729-142; 57664-345; 0378-0973; 53296-0033; 0093-5416; 51079-921; 51079-922; 57664-211; 65862-845; 69809-0127; 55154-3568; 0378-0825; 0378-0860; 12828-0072; 51407-086; 63629-2360; 69809-0126; 67835-0028; 51862-900; 57664-241; 69809-0135; 70518-3391; 0093-5376; 0093-5417; 51862-902; 60687-404; 60687-415; 63629-2362; 0378-3815; 0904-7088; 65015-706; 0093-5419; 51862-901; 60687-426; 0378-0972; 65862-844; 70518-3357; 65862-847; 0904-7089; 63552-063; 16729-141; 0093-5377; 52817-601; 57664-347; 60687-548; 63629-2361; 69809-0130; 0904-7087; 71554-025; 51862-903
UNII J60AR2IKIC
Synonyms Clozapine | Clozaril | Leponex
Chemical Information
Molecular Formula C18H19ClN4
CAS Registry Number 5786-21-0
SMILES CN1CCN(CC1)C2=NC3=C(C=CC(=C3)Cl)NC4=CC=CC=C42
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Atrioventricular block complete02.03.01.0030.009783%
Atrioventricular block first degree02.03.01.0040.010028%
Atrioventricular block second degree02.03.01.005--
Aura17.02.07.0110.001223%-
Autonomic nervous system imbalance08.01.01.010; 17.05.01.011; 24.06.01.0050.005503%-
B-cell lymphoma01.15.01.001; 16.28.01.0010.009783%-
Benign prostatic hyperplasia21.04.02.001---
Bile duct stone09.02.02.003---
Bipolar I disorder19.16.01.0020.002446%-
Bladder cancer16.08.01.001; 20.03.04.001---
Bladder dilatation20.03.01.0070.006726%-
Bladder neoplasm16.08.03.002; 20.03.04.0020.001834%-
Blood creatine phosphokinase increased13.04.01.001--
Blood triglycerides increased13.12.03.001---
Blood uric acid increased13.02.04.001---
Body temperature decreased13.15.01.010---
Body temperature increased13.15.01.001---
Bradycardia02.03.02.002---
Brain hypoxia17.08.02.009; 22.02.02.010; 24.04.06.0220.003669%-
Breast cancer16.10.01.001; 21.05.01.003---
Breast cancer stage IV16.10.01.003; 21.05.01.0100.001834%-
Breast cyst16.14.01.004; 21.05.01.0060.001223%-
Breast enlargement21.05.04.001---
Breast mass21.05.04.0020.004280%-
Breast pain21.05.05.003--
Bronchitis11.01.09.001; 22.07.01.001--
Budd-Chiari syndrome09.01.06.001; 24.01.03.0010.001223%
Bulimia nervosa14.03.03.001; 19.09.01.0060.001834%-
Bundle branch block02.03.01.0090.001223%-
Bundle branch block left02.03.01.0070.015530%-
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ADReCS-Target
Drug Name ADR Term Target
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