Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Apixaban
Drug ID BADD_D00151
Description Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FDA on December 28, 2012[L6043].
Indications and Usage Apixaban is to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation. It has also been used to lower the risk of developing venous thrombosis post-orthopedic surgical procedures.
Marketing Status Prescription
ATC Code B01AF02
DrugBank ID DB06605
KEGG ID D03213
MeSH ID C522181
PubChem ID 10182969
TTD Drug ID D0I5HF
NDC Product Code 0003-0893; 65129-1344; 55111-980; 50193-0893; 63629-8432; 16436-0113; 70366-001; 46708-908; 52048-0420; 63850-8085; 42816-0893; 14445-150; 59651-051; 53747-062; 65015-897; 55154-0613; 66174-0091; 76397-007; 75945-060; 24196-190; 15308-1221; 12783-0894; 66651-921; 63415-0520; 70518-1861; 66039-925; 65372-1196; 55154-0612; 12783-0893; 69989-0006; 76397-010; 42765-025; 76072-1017; 14501-0089; 67835-0015; 69037-0023; 50090-1437; 0003-0894; 58623-0137; 0003-3764; 42816-0894; 67296-1673; 58032-2028; 50090-1436; 65727-081; 14445-014; 63629-7747; 14445-149
Synonyms apixaban | Eliquis | BMS 562247 | BMS562247 | BMS-562247-01 | BMS-562247
Chemical Information
Molecular Formula C25H25N5O4
CAS Registry Number 503612-47-3
SMILES COC1=CC=C(C=C1)N2C3=C(CCN(C3=O)C4=CC=C(C=C4)N5CCCCC5=O)C(=N2)C(=O)N
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Amaurosis fugax06.02.02.005; 17.08.04.002; 24.04.06.0060.000795%Not Available
Amnesia17.03.02.001; 19.20.01.001--
Amyloidosis10.02.05.0010.000276%Not Available
Amyotrophic lateral sclerosis17.05.05.0040.000069%Not Available
Anaemia01.03.02.0010.045307%
Anaemia macrocytic01.03.02.002; 14.12.01.0020.000265%Not Available
Anal fissure07.03.01.0020.000265%
Anal fistula07.11.05.0020.000265%
Anaphylactic reaction10.01.07.001; 24.06.03.006--
Anaphylactic shock10.01.07.002; 24.06.02.004--Not Available
Aneurysm24.02.01.0010.000553%Not Available
Angina pectoris02.02.02.002; 24.04.04.002--
Angina unstable02.02.02.004; 24.04.04.004--Not Available
Angioedema10.01.05.009; 23.04.01.001--Not Available
Ankle fracture12.04.01.005; 15.08.03.005--
Anorectal disorder07.03.01.0010.000265%Not Available
Anosmia17.04.04.001; 22.04.03.006--
Anuria20.01.03.002--Not Available
Anxiety19.06.02.002--
Aortic aneurysm24.02.03.0010.001722%Not Available
Aortic aneurysm rupture24.02.03.0030.000173%Not Available
Aortic dissection24.02.03.0020.001722%Not Available
Aortic stenosis24.04.01.0010.001457%Not Available
Aortic thrombosis24.01.09.0010.000662%Not Available
Aortic valve incompetence02.07.03.001--Not Available
Aortic valve stenosis02.07.03.0040.001060%Not Available
Apathy19.04.04.002--Not Available
Aphasia17.02.03.001; 19.21.01.001--
Appendicitis07.19.01.001; 11.01.07.0010.001192%
Arrhythmia02.03.02.0010.007286%Not Available
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