Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Toxic epidermal necrolysis
ADR ID BADD_A04359
ADR Hierarchy
12      Injury, poisoning and procedural complications
12.03      Exposures, chemical injuries and poisoning
12.03.01      Poisoning and toxicity
12.03.01.015      Toxic epidermal necrolysis
23      Skin and subcutaneous tissue disorders
23.03      Epidermal and dermal conditions
23.03.01      Bullous conditions
23.03.01.008      Toxic epidermal necrolysis
11      Infections and infestations
11.07      Ancillary infectious topics
11.07.01      Inflammatory disorders following infection
11.07.01.006      Toxic epidermal necrolysis
10      Immune system disorders
10.01      Allergic conditions
10.01.01      Allergies to foods, food additives, drugs and other chemicals
10.01.01.006      Toxic epidermal necrolysis
Description A disorder characterized by greater than 30% total body skin area separation of dermis. The syndrome is thought to be a hypersensitivity complex affecting the skin and the mucous membranes. [CTCAE] Rare cutaneous eruption characterized by extensive KERATINOCYTE apoptosis resulting in skin detachment with mucosal involvement. It is often provoked by the use of drugs (e.g., antibiotics and anticonvulsants) or associated with PNEUMONIA, MYCOPLASMA. It is considered a continuum of Toxic Epidermal Necrolysis. | An exfoliative disease of skin seen primarily in adults and characterized by flaccid bullae and spreading erythema so that the skin has the appearance of being scalded. It results primarily from a toxic reaction to various drugs, but occasionally occurs as a result of infection, neoplastic conditions, or other exposure. [MeSH]
MedDRA Code 10044223
MeSH ID D013262
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Drug eruption Lyell syndrome type | Epidermal necrolysis | Lyell | Lyell syndrome | Lyell's disease | Lyell's syndrome | Necrolysis epidermal | Necrolysis epidermal toxic (Lyell type) | Syndrome Lyell's | TEN | Toxic epideoneal necrolysis | Toxic epidermal necrolysis | Stevens-Johnson Syndrome | Stevens Johnson Syndrome | Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum | Stevens Johnson Syndrome Toxic Epidermal Necrolysis Spectrum | Toxic Epidermal Necrolysis Stevens-Johnson Syndrome Spectrum | Toxic Epidermal Necrolysis Stevens Johnson Syndrome | Toxic Epidermal Necrolysis Stevens Johnson Syndrome Spectrum | Toxic Epidermal Necrolysis Stevens-Johnson Syndrome | Stevens Johnson Syndrome Toxic Epidermal Necrolysis | Stevens-Johnson Syndrome Toxic Epidermal Necrolysis | Mycoplasma-Induced Stevens-Johnson Syndrome | Mycoplasma Induced Stevens Johnson Syndrome | Stevens-Johnson Syndrome, Mycoplasma-Induced | Syndrome, Mycoplasma-Induced Stevens-Johnson | Mycoplasma-Induced Stevens Johnson Syndrome | Drug-Induced Stevens Johnson Syndrome | Drug Induced Stevens Johnson Syndrome | Drug-Induced Stevens-Johnson Syndrome | Drug-Induced Stevens-Johnson Syndromes | Stevens-Johnson Syndrome, Drug-Induced | Stevens-Johnson Syndromes, Drug-Induced | Epidermal Necrolysis, Toxic | Epidermal Necrolyses, Toxic | Necrolyses, Toxic Epidermal | Necrolysis, Toxic Epidermal | Toxic Epidermal Necrolyses | Toxic Epidermal Necrolysis | Scalded Skin Syndrome, Nonstaphylococcal | Lyell's Syndrome | Lyell Syndrome | Lyell's Syndromes | Syndrome, Lyell's | Syndromes, Lyell's | Nonstaphylococcal Scalded Skin Syndrome
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00838Etanercept--
BADD_D00841Ethambutol--
BADD_D00846Ethosuximide0.004226%
BADD_D00850Etodolac0.000590%
BADD_D00853Etophos--
BADD_D00854Etoposide--
BADD_D00856Etoricoxib--
BADD_D00857Etravirine--
BADD_D00868Famciclovir--
BADD_D00869Famotidine0.000045%
BADD_D00870Febuxostat0.000751%
BADD_D00871Felbamate--
BADD_D00877Fenoprofen--
BADD_D00909Flucaonazole--
BADD_D00911Flucloxacillin--
BADD_D00912Fluconazole0.000337%
BADD_D00913Flucytosine--
BADD_D00914Fludarabine--
BADD_D00915Fludarabine phosphate--
BADD_D00929Fluorometholone--
BADD_D00932Fluoxetine--
BADD_D00933Fluoxetine hydrochloride--
BADD_D00941Flurbiprofen--
BADD_D00943Flutamide--
BADD_D00948Fluvastatin--
BADD_D00949Fluvastatin sodium--
BADD_D00950Fluvoxamine--
BADD_D00962Fosaprepitant--
BADD_D00963Fosaprepitant dimeglumine--
BADD_D00964Foscarnet sodium--
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ADReCS-Target
ADR Term Drug Name Target