Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Fludarabine phosphate
Drug ID BADD_D00915
Description Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara.
Indications and Usage For the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to or whose disease has progressed during treatment with at least one standard alkylating-agent containing regimen
Marketing Status Prescription; Discontinued
ATC Code L01BB05
DrugBank ID DB01073
KEGG ID D01907
MeSH ID C042382
PubChem ID 30751
TTD Drug ID D0TO2R
NDC Product Code 45963-621; 53183-7841; 59923-604; 51916-310; 33656-0015; 63323-192; 24201-237; 25021-242; 45963-609; 58623-0043; 59605-7136
Synonyms fludarabine phosphate | fludarabine 5'-monophosphate | 9 beta-D-arabinofuranosyl-2-fluoroadenine monophosphate | fludarabine monophosphate | FaraAMP | fluoro-ara-AMP | 9H-purin-6-amine, 2-fluoro-9-(5-O-phosphono-beta-D-arabinofuranosyl)- | F-ara-AMP | NSC 312887 | NSC-312887 | Beneflur | Fludara
Chemical Information
Molecular Formula C10H13FN5O7P
CAS Registry Number 75607-67-9
SMILES C1=NC2=C(N=C(N=C2N1C3C(C(C(O3)COP(=O)(O)O)O)O)F)N
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Acute myeloid leukaemia01.10.05.001; 16.01.05.001--Not Available
Acute respiratory distress syndrome22.01.03.001--
Agitation17.02.05.012; 19.06.02.001--
Alopecia23.02.02.001--
Alveolitis allergic10.01.03.008; 22.01.01.002--Not Available
Anaemia01.03.02.001--
Anaphylactic reaction10.01.07.001; 24.06.03.006--
Anaphylactic shock10.01.07.002; 24.06.02.004--Not Available
Aneurysm24.02.01.001--Not Available
Angina pectoris02.02.02.002; 24.04.04.002--
Aplasia03.02.01.002; 08.03.04.003--Not Available
Arrhythmia02.03.02.001--Not Available
Arthralgia15.01.02.001--
Asthenia08.01.01.001--Not Available
Blindness06.02.02.001; 17.17.01.003--Not Available
Blood uric acid increased13.02.04.001--Not Available
Body temperature increased13.15.01.001--Not Available
Bronchitis11.01.09.001; 22.07.01.001--
Cardiac failure02.05.01.001--
Cardiac failure congestive02.05.01.002--Not Available
Cerebellar syndrome17.02.02.002--Not Available
Cerebrovascular accident17.08.01.007; 24.03.05.001--
Chills08.01.09.001; 15.05.03.016--
Cholelithiasis09.03.01.002--Not Available
Coma17.02.09.001--Not Available
Confusional state17.02.03.005; 19.13.01.001--
Constipation07.02.02.001--
Cough22.02.03.001--
Crystalluria20.02.01.003--Not Available
Cystitis haemorrhagic20.03.02.003--Not Available
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