Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Skin hyperpigmentation
ADR ID BADD_A04040
ADR Hierarchy
23      Skin and subcutaneous tissue disorders
23.05      Pigmentation disorders
23.05.01      Hyperpigmentation disorders
23.05.01.003      Skin hyperpigmentation
Description A disorder characterized by darkening of the skin due to excessive melanin deposition. [CTCAE] Excessive pigmentation of the skin, usually as a result of increased epidermal or dermal melanin pigmentation, hypermelanosis. Hyperpigmentation can be localized or generalized. The condition may arise from exposure to light, chemicals or other substances, or from a primary metabolic imbalance. [MeSH]
MedDRA Code 10040865
MeSH ID D017495
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Hyperpigmentation skin | Skin hyperpigmentation | Hypermelanosis | Hyperpigmentation of palms | Palmoplantar hyperpigmentation | Increased skin pigmentation | Periorbital hyperpigmentation | Hyperpigmentation | Hypermelanoses
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D01359Mechlorethamine0.002586%
BADD_D01360Mechlorethamine hydrochloride--
BADD_D01366Medroxyprogesterone acetate0.000119%
BADD_D01392Mercaptopurine--
BADD_D01418Methotrexate--
BADD_D01420Methoxsalen--
BADD_D01424Methyl aminolevulinate hydrochloride--
BADD_D01431Methylphenidate--
BADD_D01433Methylprednisolone--
BADD_D01434Methylprednisolone acetate--
BADD_D01435Methylprednisolone hemisuccinate--
BADD_D01436Methylprednisolone sodium succinate--
BADD_D01470Minocycline0.013199%
BADD_D01471Minocycline anion--
BADD_D01472Minocycline hydrochloride--
BADD_D01473Minoxidil0.000701%
BADD_D01563Nicotinate--
BADD_D01564Nicotine--
BADD_D01567Nilotinib--
BADD_D01598Ofloxacin--
BADD_D01609Omacetaxine mepesuccinate--
BADD_D01653Paclitaxel0.000280%
BADD_D01655Palifermin--
BADD_D01687Pazopanib0.000571%
BADD_D01709Penicillamine0.000113%
BADD_D01743Perphenazine--
BADD_D01773Pimecrolimus--
BADD_D01783Pirfenidone0.000482%
BADD_D01792Polidocanol--
BADD_D01799Ponatinib0.000112%
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ADReCS-Target
ADR Term Drug Name Target