Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pazopanib
Drug ID BADD_D01687
Description Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009.
Indications and Usage Treatment of advanced renal cell cancer and advanced soft tissue sarcoma (in patients previously treated with chemotherapy)
Marketing Status approved
ATC Code L01EX03
DrugBank ID DB06589
KEGG ID D05380
MeSH ID C516667
PubChem ID 10113978
TTD Drug ID Not Available
NDC Product Code Not Available
UNII 7RN5DR86CK
Synonyms pazopanib | GW 786034B | GW786034B | GW-786034B | GW 780604 | GW780604 | GW-780604 | Votrient
Chemical Information
Molecular Formula C21H23N7O2S
CAS Registry Number 444731-52-6
SMILES CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.0010.009794%-
Abdominal distension07.01.04.0010.003425%
Abdominal pain07.01.05.0020.011920%
Abdominal pain lower07.01.05.010---
Abdominal pain upper07.01.05.0030.012514%
Abdominal tenderness07.01.05.0040.000246%-
Abnormal faeces07.01.03.0010.000492%-
Accommodation disorder06.02.04.0010.000112%-
Acute abdomen07.01.06.0150.000112%-
Acute hepatic failure09.01.03.0010.000280%-
Acute pulmonary oedema02.05.02.004; 22.01.03.0050.000224%-
Acute respiratory distress syndrome10.02.01.067; 22.01.03.001; 24.03.02.0340.000280%
Ageusia07.14.03.003; 17.02.07.0010.006984%-
Alanine aminotransferase increased13.03.04.005--
Albuminuria20.02.01.0010.000112%-
Alopecia23.02.02.0010.009189%
Amnesia17.03.02.001; 19.20.01.0010.002082%
Amylase increased13.05.01.009--
Anaemia01.03.02.001--
Angina pectoris02.02.02.002; 24.04.04.0020.000336%
Angina unstable02.02.02.004; 24.04.04.0040.000112%-
Anosmia17.04.04.001; 22.04.03.0060.000112%
Anuria20.01.03.0020.000224%-
Aortic dissection24.02.03.0020.000224%-
Aphasia17.02.03.001; 19.21.01.0010.000828%
Aphonia17.02.08.009; 19.19.01.002; 22.12.03.0010.000739%
Aphthous ulcer07.05.06.0020.000414%-
Arterial thrombosis24.01.01.0020.000112%-
Arteriovenous fistula24.03.03.0010.000112%-
Arthralgia15.01.02.0010.009715%
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