Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Nicotine
Drug ID BADD_D01564
Description Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.
Indications and Usage For the relief of nicotine withdrawal symptoms and as an aid to smoking cessation.
Marketing Status Prescription; OTC; Discontinued
ATC Code N07BA01
DrugBank ID DB00184
KEGG ID D03365
MeSH ID D009538
PubChem ID 89594
TTD Drug ID D0T8GD
NDC Product Code 59779-443; 0536-5895; 0536-1108; 62011-0350; 69842-605; 59779-448; 43598-448; 68016-289; 60429-443; 11673-196; 49035-194; 66715-9804; 60505-7092; 49035-196; 0135-0194; 50090-1972; 43598-445; 0009-5400; 59450-001; 70677-0031; 60429-445; 49348-788; 0536-5896; 37808-900; 70677-0030; 0009-5401; 66715-9806; 63981-190; 37808-849; 50090-1148; 66715-9801; 63981-124; 0135-0195; 29485-5270; 70000-0115; 29485-5271; 37808-948; 43598-447; 0220-3657; 60505-7091; 55741-449; 37808-533; 60429-444; 49035-782; 11673-971; 11822-3627; 37808-707; 60505-7093; 37808-383; 50090-1697; 37808-739; 21130-269; 0363-0451; 59779-445; 70000-0113; 62011-0349; 68016-288; 28663-009; 75877-0002; 37808-911; 52922-001; 0135-0196; 11673-879; 17205-601; 70677-0032; 0536-1106; 37808-753; 11673-194; 70000-0114; 50090-2860; 66715-9803; 37808-682; 81870-001; 59450-002; 63868-734; 37808-658; 43598-446; 61252-3005; 11673-727; 0363-0455; 0536-1107; 11673-195; 0536-5894; 49035-195; 28663-010; 11673-881; 55742-003; 21130-820; 63868-735; 37808-711; 59450-003; 66715-9805; 50392-101; 11673-424; 55910-313; 11673-269; 68016-290; 69842-828; 62011-0351; 0363-0457; 66715-9802
Synonyms Nicotine | Nicotine Bitartrate | Nicotine Tartrate
Chemical Information
Molecular Formula C10H14N2
CAS Registry Number 54-11-5
SMILES CN1CCCC1C2=CN=CC=C2
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal pain07.01.05.0020.011483%
Abdominal pain upper07.01.05.003--
Abnormal dreams17.15.02.001; 19.02.03.0010.010207%Not Available
Abnormal faeces07.01.03.001--Not Available
Abortion spontaneous18.01.04.0010.007655%Not Available
Acne23.02.01.001--Not Available
Acute respiratory distress syndrome22.01.03.0010.000666%
Agitation17.02.05.012; 19.06.02.001--
Agitation neonatal17.02.05.028; 18.04.04.002; 19.06.02.0070.002552%Not Available
Amnesia17.03.02.001; 19.20.01.001--
Anaphylactic reaction10.01.07.001; 24.06.03.0060.010207%
Anaphylactic shock10.01.07.002; 24.06.02.004--Not Available
Anger19.04.02.0010.003828%Not Available
Angina pectoris02.02.02.002; 24.04.04.0020.005103%
Angioedema10.01.05.009; 23.04.01.0010.006379%Not Available
Anxiety19.06.02.0020.030620%
Apathy19.04.04.002--Not Available
Apgar score low13.15.01.0120.005103%Not Available
Aphasia17.02.03.001; 19.21.01.001--
Aphonia17.02.08.009; 19.19.01.002; 22.02.05.0240.002552%
Aphthous ulcer07.05.06.002--Not Available
Application site reaction08.02.01.006; 12.07.01.006--Not Available
Arrhythmia02.03.02.0010.005103%Not Available
Arthralgia15.01.02.001--
Arthritis15.01.01.001--
Asphyxia12.01.08.011; 22.02.02.0010.000666%Not Available
Aspiration22.02.07.0070.000666%
Asthenia08.01.01.001--Not Available
Asthma10.01.03.010; 22.03.01.0020.005103%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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