Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Skin hyperpigmentation
ADR ID BADD_A04040
ADR Hierarchy
23      Skin and subcutaneous tissue disorders
23.05      Pigmentation disorders
23.05.01      Hyperpigmentation disorders
23.05.01.003      Skin hyperpigmentation
Description A disorder characterized by darkening of the skin due to excessive melanin deposition. [CTCAE] Excessive pigmentation of the skin, usually as a result of increased epidermal or dermal melanin pigmentation, hypermelanosis. Hyperpigmentation can be localized or generalized. The condition may arise from exposure to light, chemicals or other substances, or from a primary metabolic imbalance. [MeSH]
MedDRA Code 10040865
MeSH ID D017495
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Hyperpigmentation skin | Skin hyperpigmentation | Hypermelanosis | Hyperpigmentation of palms | Palmoplantar hyperpigmentation | Increased skin pigmentation | Periorbital hyperpigmentation | Hyperpigmentation | Hypermelanoses
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00912Fluconazole0.000157%
BADD_D00917Fludrocortisone--
BADD_D00918Fludrocortisone acetate--
BADD_D00924Fluocinolone acetonide--
BADD_D00931Fluorouracil0.000184%
BADD_D01086Hydrocortisone--
BADD_D01091Hydrocortisone sodium succinate--
BADD_D01110Hydroxyurea0.000739%
BADD_D01119Ibrutinib0.000224%
BADD_D01127Idarubicin--
BADD_D01133Ifosfamide--
BADD_D01136Imatinib0.000716%
BADD_D01137Imatinib mesylate--
BADD_D01139Imipramine0.002530%
BADD_D01142Imiquimod0.000966%
BADD_D01150Indinavir--
BADD_D01151Indinavir sulfate--
BADD_D01204Isoniazid0.002780%
BADD_D01213Isotretinoin--
BADD_D01222Ixabepilone--
BADD_D01239Lactic acid--
BADD_D01241Lamisil--
BADD_D01243Lamotrigine0.000304%
BADD_D01250Lasofoxifene--
BADD_D01252Leflunomide0.000857%
BADD_D01253Lenalidomide0.016492%
BADD_D01275Levofloxacin0.000405%
BADD_D01281Levonorgestrel0.004302%
BADD_D01309Lomefloxacin--
BADD_D01310Lomefloxacin hydrochloride--
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ADReCS-Target
ADR Term Drug Name Target