Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Ifosfamide
Drug ID BADD_D01133
Description Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent.
Indications and Usage Used as a component of various chemotherapeutic regimens as third-line therapy for recurrent or refractory germ cell testicular cancer. Also used as a component of various chemotherapeutic regimens for the treatment of cervical cancer, as well as in conjunction with surgery and/or radiation therapy in the treatment of various soft tissue sarcomas. Other indications include treatment of osteosarcoma, bladder cancer, ovarian cancer. small cell lung cancer, and non-Hodgkin's lymphoma.
Marketing Status Prescription; Discontinued
ATC Code L01AA06
DrugBank ID DB01181
KEGG ID D00343
MeSH ID D007069
PubChem ID 3690
TTD Drug ID D02TLO
NDC Product Code 10019-925; 63323-142; 15308-0411; 10019-929; 57884-0006; 0338-3991; 0143-9530; 10019-926; 0143-9531; 10019-927; 65124-0001; 0703-3427; 0338-3993; 0703-3429
Synonyms Ifosfamide | Isofosfamide | Isophosphamide | Iphosphamide | Iso-Endoxan | Iso Endoxan | Holoxan | NSC-109,724 | NSC 109,724 | NSC109,724 | NSC-109724 | NSC 109724 | NSC109724 | Asta Z 4942
Chemical Information
Molecular Formula C7H15Cl2N2O2P
CAS Registry Number 3778-73-2
SMILES C1CN(P(=O)(OC1)NCCCl)CCCl
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.0020.001332%
Acidosis14.01.03.002--
Acute leukaemia01.10.02.001; 16.01.02.001--Not Available
Acute lymphocytic leukaemia01.10.01.001; 16.01.01.001--Not Available
Acute myeloid leukaemia01.10.05.001; 16.01.05.001--Not Available
Acute promyelocytic leukaemia01.10.05.003; 16.01.05.003--Not Available
Acute respiratory distress syndrome22.01.03.001--
Agitation17.02.05.012; 19.06.02.0010.001066%
Agranulocytosis01.02.03.001--Not Available
Alopecia23.02.02.0010.002131%
Alveolitis allergic10.01.03.008; 22.01.01.002--Not Available
Amenorrhoea05.05.01.002; 21.01.02.001--
Aminoaciduria03.08.04.003; 14.14.04.003; 20.02.01.024--Not Available
Amnesia17.03.02.001; 19.20.01.001--
Anaemia01.03.02.0010.003730%
Anaemia neonatal01.03.02.011; 18.04.03.002--Not Available
Anaphylactic reaction10.01.07.001; 24.06.03.006--
Anaphylactic shock10.01.07.002; 24.06.02.004--Not Available
Angina pectoris02.02.02.002; 24.04.04.002--
Angioedema10.01.05.009; 23.04.01.001--Not Available
Aplasia03.02.01.002; 08.03.04.0030.000533%Not Available
Arrhythmia02.03.02.001--Not Available
Arrhythmia supraventricular02.03.03.001--Not Available
Arthralgia15.01.02.001--
Asterixis09.01.03.004; 17.01.06.001--Not Available
Asthenia08.01.01.001--Not Available
Atrial fibrillation02.03.03.002--
Atrial flutter02.03.03.003--
Azoospermia21.03.03.001--
Back pain15.03.04.0050.000533%
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ADReCS-Target
Drug Name ADR Term Target
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