Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Hydrocortisone sodium succinate
Drug ID BADD_D01091
Description Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex.[A188387] Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone.[A188420] Hydrocortisone was granted FDA approval on 5 August 1952.[L10574]
Indications and Usage Otic solutions are indicated for infections of the external auditory canal caused by susceptible organisms and with inflammation.[L10529,L10532] Hydrocortisone tablets are indicated for certain endocrine, rheumatic, collagen, allergic, ophthalmic, respiratory, hematologic, neoplastic, edematous, gastrointestinal, and other conditions.[L10535] A hydrocortisone enema is indicated for ulcerative colitis,[L10538] a topical ointment with antibiotics is indicated for corticosteroid responsive dermatoses with infections,[L7772] and a topical cream with [acyclovir] is indicated to treat cold sores.[L7321] Oral granules of hydrocortisone are used as a replacement therapy for Adrenocortical Insufficiency (AI) in children under 17 years of age.[L16533]
Marketing Status approved; vet_approved
ATC Code S01CB03; H02AB09; S01BA02; C05AA01; D07AA02; A01AC03; D07XA01; S02BA01; A07EA02
DrugBank ID DB00741
KEGG ID D00978
MeSH ID D006854
PubChem ID 23694214
TTD Drug ID D0KR5B
NDC Product Code 22552-0007; 0009-0005; 0009-0013; 0009-0825; 0009-0016; 0009-0011; 64958-0020; 55154-3942
UNII 50LQB69S1Z
Synonyms Hydrocortisone | Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)- | Cortisol | Cortef | Hydrocortisone, (11 alpha)-Isomer | Epicortisol | 11-Epicortisol | 11 Epicortisol | Hydrocortisone, (9 beta,10 alpha,11 alpha)-Isomer | Cortifair | Cortril
Chemical Information
Molecular Formula C25H33NaO8
CAS Registry Number 125-04-2
SMILES CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4(C(=O)COC(=O)CCC(=O)[O-])O)C)O.[Na+]
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.001--
Abscess sterile08.01.05.008---
Acne23.02.01.001---
Alkalosis hypokalaemic14.01.02.002---
Alopecia23.02.02.001--
Anaphylactic reaction10.01.07.001; 24.06.03.006--
Anaphylactoid reaction10.01.07.003; 24.06.03.007---
Angioedema10.01.05.009; 22.04.02.008; 23.04.01.001---
Arachnoiditis12.02.04.002; 17.06.01.001--
Arrhythmia02.03.02.001---
Blindness06.02.10.003; 17.17.01.003---
Bradycardia02.03.02.002---
Burning sensation08.01.09.029; 17.02.06.001---
Carbohydrate tolerance decreased13.02.02.003---
Cardiac arrest02.03.04.001--
Cardiac failure congestive02.05.01.002---
Cardiomegaly02.04.02.001---
Cataract subcapsular06.06.01.002---
Circulatory collapse24.06.02.001---
Cushingoid05.01.01.002; 14.11.01.006; 19.07.03.001; 24.08.02.004--
Depression19.15.01.001--
Dermatitis allergic10.01.03.014; 23.03.04.003---
Diabetes mellitus05.06.01.001; 14.06.01.001---
Dry skin23.03.03.001--
Ecchymosis01.01.03.001; 23.06.01.001; 24.07.06.002---
Erythema23.03.06.001---
Euphoric mood19.04.02.006--
Exophthalmos05.02.02.002; 06.09.04.001---
Fat embolism12.01.08.003; 24.01.01.012---
Fluid retention14.05.06.002; 20.01.02.003---
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