Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Optic neuritis
ADR ID BADD_A03182
ADR Hierarchy
17      Nervous system disorders
17.04      Cranial nerve disorders (excl neoplasms)
17.04.05      Optic nerve disorders NEC
17.04.05.001      Optic neuritis
10      Immune system disorders
10.02      Immune disorders NEC
10.02.01      Immune and associated conditions NEC
10.02.01.097      Optic neuritis
06      Eye disorders
06.04      Ocular infections, irritations and inflammations
06.04.08      Optic nerve infections and inflammations
06.04.08.002      Optic neuritis
Description Inflammation of the optic nerve. Commonly associated conditions include autoimmune disorders such as MULTIPLE SCLEROSIS, infections, and granulomatous diseases. Clinical features include retro-orbital pain that is aggravated by eye movement, loss of color vision, and contrast sensitivity that may progress to severe visual loss, an afferent pupillary defect (Marcus-Gunn pupil), and in some instances optic disc hyperemia and swelling. Inflammation may occur in the portion of the nerve within the globe (neuropapillitis or anterior optic neuritis) or the portion behind the globe (retrobulbar neuritis or posterior optic neuritis). [MeSH]
MedDRA Code 10030942
MeSH ID D009902; D010211; D012173
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Bilateral optic neuritis | Neuritis bulbar | Neuritis optic | Neuritis retrobulbar | Optic disc inflammation | Optic neuritis | Optic neuritis NOS | Optic neuritis retrobulbar | Optic neuritis, unspecified | Optic papillitis | Opticoneuroretinitis | Other optic neuritis | Papillitis optic | Retro-bulbar neuritis | Retrobulbar neuritis | Retrobulbar neuritis (acute) | Neuroretinitis | Optic Neuritis | Neuritides, Optic | Neuritis, Optic | Optic Neuritides | Neuropapillitis | Neuropapillitides | Anterior Optic Neuritis | Anterior Optic Neuritides | Neuritides, Anterior Optic | Neuritis, Anterior Optic | Optic Neuritides, Anterior | Optic Neuritis, Anterior | Retrobulbar Neuritis | Neuritides, Retrobulbar | Neuritis, Retrobulbar | Retrobulbar Neuritides | Posterior Optic Neuritis | Neuritides, Posterior Optic | Neuritis, Posterior Optic | Optic Neuritides, Posterior | Optic Neuritis, Posterior | Posterior Optic Neuritides
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00855Etoposide phosphate--
BADD_D00861Exemestane0.001046%
BADD_D00877Fenoprofen--
BADD_D00878Fenoprofen calcium--
BADD_D00914Fludarabine--
BADD_D00915Fludarabine phosphate--
BADD_D00917Fludrocortisone--
BADD_D00918Fludrocortisone acetate--
BADD_D00932Fluoxetine--
BADD_D00933Fluoxetine hydrochloride--
BADD_D00941Flurbiprofen--
BADD_D00965Fosfomycin--
BADD_D00966Fosfomycin tromethamine--
BADD_D00981Gabapentin--
BADD_D00998Gallium cation--
BADD_D01000Gallium nitrate--
BADD_D01009Gemcitabine--
BADD_D01020Glatiramer--
BADD_D01021Glatiramer acetate--
BADD_D01046Guanfacine0.000173%
BADD_D01063Hepatitis b vaccine--
BADD_D01064Hepatitis b vaccine (recombinant)--
BADD_D01086Hydrocortisone--
BADD_D01103Hydroxychloroquine--
BADD_D01120Ibuprofen--
BADD_D01136Imatinib0.001119%
BADD_D01137Imatinib mesylate--
BADD_D01149Indapamide--
BADD_D01167Interferon alfa-2b--
BADD_D01204Isoniazid0.004170%
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