Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Exemestane
Drug ID BADD_D00861
Description Exemestane is an oral steroidal aromatase inhibitor used in the adjuvant treatment of hormonally-responsive (also called hormone-receptor-positive, estrogen-responsive) breast cancer in postmenopausal women. It irreversibly binds to the active site of the enzyme resulting in permanent inhibition.
Indications and Usage For the treatment of advanced breast cancer in postmenopausal women whose disease has progressed following tamoxifen therapy.
Marketing Status Prescription
ATC Code L02BG06
DrugBank ID DB00990
KEGG ID D00963
MeSH ID C056516
PubChem ID 60198
TTD Drug ID D0D2VS
NDC Product Code 62157-091; 51991-005; 59057-007; 73377-132; 64918-0621; 50090-5193; 52128-134; 63629-2056; 59057-008; 69097-316; 0009-7663; 62756-981; 68382-383; 64181-0005; 0832-0595; 44278-025; 0378-5001; 65427-030; 71921-190; 46439-8746; 49386-026; 65162-240; 53104-7666; 47781-108; 59762-2858; 0054-0080; 65129-1217; 70771-1374; 64918-0622; 65089-0046
Synonyms exemestane | examestane | 6-methyleneandrosta-1,4-diene-3,17-dione | FCE 24304 | FCE-24304 | Aromasil | Aromasin | Aromasine
Chemical Information
Molecular Formula C20H24O2
CAS Registry Number 107868-30-4
SMILES CC12CCC3C(C1CCC2=O)CC(=C)C4=CC(=O)C=CC34C
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.003--
Acute hepatic failure09.01.03.0010.001875%Not Available
Aggression19.05.01.001--Not Available
Alanine aminotransferase increased13.03.01.003--
Alopecia23.02.02.0010.035945%
Amnesia17.03.02.001; 19.20.01.0010.004793%
Anaemia01.03.02.001--
Angina pectoris02.02.02.002; 24.04.04.002--
Angioedema10.01.05.009; 23.04.01.001--Not Available
Anxiety19.06.02.002--
Arthralgia15.01.02.0010.117419%
Arthritis15.01.01.0010.007189%
Arthropathy15.01.01.0030.009585%Not Available
Ascites02.05.04.002; 07.07.01.001; 09.01.05.0030.007189%
Aspartate aminotransferase increased13.03.01.006--
Asthenia08.01.01.0010.028756%Not Available
Atrial fibrillation02.03.03.002--
Back pain15.03.04.0050.016774%
Bladder cancer16.08.01.001; 20.03.04.001--Not Available
Blood bilirubin increased13.03.01.0080.004793%
Blood glucose increased13.02.02.0020.011982%Not Available
Blood pressure abnormal13.14.03.0010.004793%Not Available
Blood pressure increased13.14.03.005--Not Available
Body temperature increased13.15.01.001--Not Available
Bone disorder15.02.04.0040.009585%Not Available
Bone pain15.02.01.0010.023963%
Breast cancer16.10.01.001; 21.05.01.0030.025005%Not Available
Breast pain21.05.05.0030.004793%
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ADReCS-Target
Drug Name ADR Term Target
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