Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Mutism
ADR ID BADD_A02911
ADR Hierarchy
19      Psychiatric disorders
19.19      Communication disorders and disturbances
19.19.01      Communications disorders
19.19.01.001      Mutism
17      Nervous system disorders
17.02      Neurological disorders NEC
17.02.08      Speech and language abnormalities
17.02.08.007      Mutism
Description The inability to generate oral-verbal expression, despite normal comprehension of speech. This may be associated with BRAIN DISEASES or MENTAL DISORDERS. Organic mutism may be associated with damage to the FRONTAL LOBE; BRAIN STEM; THALAMUS; and CEREBELLUM. Selective mutism is a psychological condition that usually affects children characterized by continuous refusal to speak in social situations by a child who is able and willing to speak to selected persons. Kussmal aphasia refers to mutism in psychosis. (From Fortschr Neurol Psychiatr 1994; 62(9):337-44) [MeSH]
MedDRA Code 10028403
MeSH ID D009155
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Mutism | Mutism NEC | Silence | Mutisms | Selective Mutism | Mutism, Selective | Mutism, Voluntary | Mutisms, Voluntary | Voluntary Mutism | Voluntary Mutisms | Mutism, Elective | Elective Mutism | Elective Mutisms | Mutisms, Elective | Mutism, Organic | Mutisms, Organic | Organic Mutism | Organic Mutisms | Kussmaul Aphasia | Aphasia, Kussmaul | Kussmaul's Aphasia | Aphasia, Kussmaul's | Kussmauls Aphasia | Mutism, Conversion | Conversion Mutism | Conversion Mutisms | Mutisms, Conversion
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00165Aripiprazole0.000079%
BADD_D00195Azathioprine--
BADD_D00349Capecitabine0.000112%
BADD_D00445Chlorpromazine0.000677%
BADD_D00499Clomipramine--
BADD_D00500Clomipramine hydrochloride--
BADD_D00504Clopidogrel0.000053%
BADD_D00511Clozapine0.007337%
BADD_D00932Fluoxetine0.000039%
BADD_D00950Fluvoxamine--
BADD_D00951Fluvoxamine maleate--
BADD_D00981Gabapentin0.000023%
BADD_D01133Ifosfamide--
BADD_D01203Isoflurane0.000179%
BADD_D01281Levonorgestrel--
BADD_D01318Lorazepam0.000031%
BADD_D01431Methylphenidate0.000090%
BADD_D01476Mirtazapine0.000080%
BADD_D01496Montelukast0.000050%
BADD_D01599Olanzapine0.000631%
BADD_D01637Oxcarbazepine0.000170%
BADD_D01765Phenytoin0.000191%
BADD_D01835Pregabalin0.000332%
BADD_D01888Quetiapine0.000055%
BADD_D01951Risperidone0.001030%
BADD_D02010Sertraline0.000045%
BADD_D02100Sunitinib0.000112%
BADD_D02105Tacrolimus0.002198%
BADD_D02236Tofacitinib0.001181%
BADD_D02337Varenicline--
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