Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Hepatic necrosis
ADR ID BADD_A02009
ADR Hierarchy
09      Hepatobiliary disorders
09.01      Hepatic and hepatobiliary disorders
09.01.07      Hepatocellular damage and hepatitis NEC
09.01.07.002      Hepatic necrosis
Description A disorder characterized by a necrotic process occurring in the hepatic parenchyma. [CTCAE]
MedDRA Code 10019692
MeSH ID Not Available
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Acute and subacute necrosis of liver | Hepatic lobule necrosis | Hepatic necrosis | Hepatic necrosis extensive | Hepatitis necrotizing | Liver necrosis | Necrosis hepatocellular | Necrosis liver | Necrosis liver focal | Subacute hepatic necrosis | Hepatitis necrotising
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00023Acetaminophen0.000140%
BADD_D00025Acetazolamide--
BADD_D00026Acetazolamide sodium--
BADD_D00029Acetyl sulfisoxazole--
BADD_D00041Adalimumab--
BADD_D00076Allopurinol0.000198%
BADD_D00129Amoxicillin0.000005%
BADD_D00143Anidulafungin--
BADD_D00195Azathioprine0.000375%
BADD_D00203Azithromycin--
BADD_D00204Azithromycin dihydrate--
BADD_D00205Azithromycin monohydrate--
BADD_D00210Balsalazide--
BADD_D00318Busulfan0.000139%
BADD_D00349Capecitabine0.000139%
BADD_D00354Captopril--
BADD_D00356Carbamazepine0.000220%
BADD_D00376Caspofungin--
BADD_D00377Caspofungin acetate--
BADD_D00390Cefotaxime0.000213%
BADD_D00410Celecoxib--
BADD_D00415Cerivastatin--
BADD_D00463Cidofovir--
BADD_D00464Cidofovir dihydrate--
BADD_D00471Ciprofloxacin--
BADD_D00472Ciprofloxacin hydrochloride--
BADD_D00475Citalopram0.000022%
BADD_D00476Citalopram hydrobromide--
BADD_D00499Clomipramine--
BADD_D00511Clozapine--
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ADReCS-Target
ADR Term Drug Name Target