Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Caspofungin
Drug ID BADD_D00376
Description Caspofungin (brand name Cancidas worldwide) is an antifungal drug and the first member of a new drug class called the echinocandins, as coined by Merck & Co., Inc. It is typically administered intravenously. It shows activity against infections with Aspergillus and Candida, and works by inhibiting β(1,3)-D-Glucan of the fungal cell wall.
Indications and Usage For the treatment of esophageal candidiasis and invasive aspergillosis in patients who are refractory to or intolerant of other therapies.
Marketing Status approved
ATC Code J02AX04
DrugBank ID DB00520
KEGG ID D07626
MeSH ID D000077336
PubChem ID 2826718
TTD Drug ID D00ZCN
NDC Product Code Not Available
UNII F0XDI6ZL63
Synonyms Caspofungin | Cancidas | MK 0991 | MK-0991 | MK0991 | Caspofungin MSD | L 743,872 | L-743,872 | L743,872 | L-743872 | L743872 | L 743872 | Caspofungin Acetate
Chemical Information
Molecular Formula C52H88N10O15
CAS Registry Number 162808-62-0
SMILES CCC(C)CC(C)CCCCCCCCC(=O)NC1CC(C(NC(=O)C2C(CCN2C(=O)C(NC(=O)C(NC(=O)C3CC(CN3C(=O) C(NC1=O)C(C)O)O)C(C(C4=CC=C(C=C4)O)O)O)C(CCN)O)O)NCCN)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001---
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.003--
Acquired immunodeficiency syndrome10.03.03.001; 11.05.17.007---
Activated partial thromboplastin time prolonged13.01.02.001--
Acute myeloid leukaemia01.10.05.001; 16.01.05.0010.000150%-
Acute respiratory distress syndrome10.02.01.067; 22.01.03.001; 24.03.02.034--
Agranulocytosis01.02.03.0010.000299%-
Alanine aminotransferase increased13.03.04.005--
Anaemia01.03.02.001--
Anaphylactic shock10.01.07.002; 24.06.02.004---
Angioedema10.01.05.009; 22.04.02.008; 23.04.01.001---
Anxiety19.06.02.002--
Arrhythmia02.03.02.001---
Arthralgia15.01.02.001--
Ascites02.05.04.002; 07.07.01.001; 09.01.05.003--
Aspartate aminotransferase increased13.03.04.011--
Asthenia08.01.01.001---
Atrial fibrillation02.03.03.002--
Back pain15.03.04.005--
Bacteraemia11.01.11.001--
Bilirubin conjugated increased13.03.04.014---
Blood albumin decreased13.09.01.001---
Blood bicarbonate decreased13.02.01.035--
Blood bilirubin increased13.03.04.018--
Blood calcium decreased13.11.01.002---
Blood chloride decreased13.11.01.004---
Blood chloride increased13.11.01.005---
Blood creatinine increased13.13.01.004--
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