| Pharmaceutical Information |
| Drug Name |
Acetyl sulfisoxazole |
| Drug ID |
BADD_D00029 |
| Description |
Sulfisoxazole acetyl is an ester of _sulfisoxazole_, a broad-spectrum sulfanilamide and a synthetic analog of para-aminobenzoic acid (PABA) with antibacterial activity. Sulfisoxazole acetyl competes with PABA for the bacterial enzyme, _dihydropteroate synthase_, preventing the incorporation of PABA into dihydrofolic acid, which is the precursor of folic acid. This process causes an inhibition of bacterial folic acid synthesis and de novo synthesis of purines and pyrimidines, resulting in cell growth arrest and cell death [L2788].
It is often combined with erythromycin to treat acute otitis media caused by the bacteria, haemophilus influenzae [L2790]. |
| Indications and Usage |
Acute, recurrent or chronic urinary tract infections (primarily pyelonephritis, pyelitis and cystitis) due to susceptible organisms (usually Escherichia coli, Klebsiella-Enterobacter, staphylococcus, Proteus mirabilis and, less frequently, Proteus vulgaris) in the absence of obstructive uropathy or foreign bodies [L2804]
Meningococcal meningitis where the organism has been demonstrated to be susceptible. Haemophilus influenzae meningitis as adjunctive therapy with parenteral streptomycin [L2804]
Meningococcal meningitis prophylaxis [L2804].
Acute otitis media due to Haemophilus influenzae when used concomitantly with adequate doses of penicillin or erythromycin (see appropriate labeling for prescribing information) [L2804].
Trachoma, inclusion conjunctivitis, nocardiosis, chancroid, toxoplasmosis as adjunctive therapy with pyrimethamine. Malaria due to chloroquine-resistant strains of Plasmodium falciparum, when used as adjunctive therapy [L2804].
Currently, the increasing frequency of resistant organisms is a limitation of the usefulness of antibacterial agents including the sulfonamides, especially in the treatment of chronic and recurrent urinary tract infections [L2804]. |
| Marketing Status |
approved; vet_approved |
| ATC Code |
Not Available |
| DrugBank ID |
DB14033
|
| KEGG ID |
Not Available
|
| MeSH ID |
C005387
|
| PubChem ID |
6662
|
| TTD Drug ID |
Not Available
|
| NDC Product Code |
Not Available |
| UNII |
WBT5QH3KED
|
| Synonyms |
acetyl sulfisoxazole |
|
| Chemical Information |
| Molecular Formula |
C13H15N3O4S |
| CAS Registry Number |
80-74-0 |
| SMILES |
CC1=C(ON=C1C)N(C(=O)C)S(=O)(=O)C2=CC=C(C=C2)N |
| Chemical Structure |
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| ADRs Induced by Drug |
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