Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Depressed level of consciousness
ADR ID BADD_A01205
ADR Hierarchy
17      Nervous system disorders
17.02      Neurological disorders NEC
17.02.04      Disturbances in consciousness NEC
17.02.04.002      Depressed level of consciousness
Description A disorder characterized by a decrease in ability to perceive and respond. [CTCAE] Organic mental disorders in which there is impairment of the ability to maintain awareness of self and environment and to respond to environmental stimuli. Dysfunction of the cerebral hemispheres or brain stem RETICULAR FORMATION may result in this condition. [MeSH]
MedDRA Code 10012373
MeSH ID D003244; D000405
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Arousal difficult | Central nervous system depression NOS | CNS depression | CNS depression NOS | Consciousness clouding | Consciousness decreased | Depressed level of consciousness | Depression central nervous system | Obtundation | Obtundation mental | Semi-coma | Semi-conscious | Sensorium decreased | Unconscious partial | Obnubilation | Alertness decreased | Precoma | Coma vigil | Consciousness Disorders | Consciousness Disorder | Consciousness, Level Depressed | Depressed Level of Consciousness | Semiconsciousness | Consciousness, Level Altered | Altered Level of Consciousness
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00020Acebutolol hydrochloride--
BADD_D00023Acetaminophen0.000161%
BADD_D00032Acetylcysteine0.000149%
BADD_D00039Acyclovir0.000784%
BADD_D00040Acyclovir sodium--
BADD_D00052Albendazole0.004226%
BADD_D00085Alprazolam0.001340%
BADD_D00097Amantadine0.000393%
BADD_D00118Amitriptyline--
BADD_D00121Amlodipine0.000038%
BADD_D00126Amobarbital--
BADD_D00130Amphetamine0.000161%
BADD_D00132Amphotericin b--
BADD_D00157Aprepitant--
BADD_D00165Aripiprazole0.001680%
BADD_D00167Armodafinil0.001095%
BADD_D00178Atenolol0.000126%
BADD_D00189Atropine--
BADD_D00198Azelastine0.000157%
BADD_D00209Baclofen0.002612%
BADD_D00240Benzonatate0.000047%
BADD_D00263Betaxolol--
BADD_D00269Bexarotene--
BADD_D00277Bisoprolol0.002512%
BADD_D00278Bisoprolol fumarate--
BADD_D00294Brimonidine0.000564%
BADD_D00296Brinzolamide0.000468%
BADD_D00299Bromazepam--
BADD_D00304Bromocriptine0.001319%
BADD_D00308Bupivacaine0.000357%
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ADReCS-Target
ADR Term Drug Name Target