Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Bisoprolol fumarate
Drug ID BADD_D00278
Description Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs.[A180472] Bisoprolol is generally well tolerated, likely due to its β1-adrenergic receptor selectivity and is a useful alternative to non-selective β-blocker drugs in the treatment of hypertension such as [Carvedilol] and [Labetalol]. It may be used alone or in combination with other drugs to manage hypertension[L7219] and can be useful in patients with chronic obstructive pulmonary disease (COPD) due to its receptor selectivity.[A180562]
Indications and Usage Bisoprolol is indicated for the treatment of mild to moderate hypertension.[L7219] It may be used off-label to treat heart failure, atrial fibrillation, and angina pectoris.[A180460,A180463]
Marketing Status approved
ATC Code C07AB07
DrugBank ID DB00612
KEGG ID D00634
MeSH ID D017298
PubChem ID 6917733
TTD Drug ID D0K3ZR
NDC Product Code 53747-009; 51407-646; 52817-271; 63187-871; 70954-456; 72578-112; 16714-530; 71335-2178; 72888-093; 38779-3142; 52932-0720; 65862-087; 65862-086; 70771-1727; 61281-5250; 29300-127; 51407-645; 62332-603; 52817-270; 72578-111; 65862-380; 29300-126; 46708-603; 61919-787; 63629-6907; 10920-571; 57451-1192; 16714-529; 70771-1726; 66064-1004; 60687-679; 72888-092; 65085-0051; 46708-604; 50268-127; 62332-604; 70954-455; 71335-1678
UNII UR59KN573L
Synonyms Bisoprolol | Bisoprolol Fumarate (1:1) Salt, (+-)-Isomer | Bisoprolol Fumarate (2:1) Salt, (+-)-Isomer | Bisoprolol Hydrochloride | Hydrochloride, Bisoprolol | Bisoprolol Methanesulfonate Salt | Bisoprolol, (+-)-Isomer | Bisoprolol, Fumarate (1:1) Salt | Bisoprolol, Fumarate (2:1) Salt | CL-297939 | CL 297939 | CL297939 | Concor | EMD-33512 | EMD 33512 | EMD33512 | Bisoprolol Fumarate | Fumarate, Bisoprolol | Bisoprolol, (-)-Isomer
Chemical Information
Molecular Formula C22H35NO8
CAS Registry Number 104344-23-2
SMILES CC(C)NCC(COC1=CC=C(C=C1)COCCOC(C)C)O.C(=CC(=O)O)C(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.003--
Abnormal dreams17.15.02.001; 19.02.03.001---
Acne23.02.01.001---
Agranulocytosis01.02.03.001---
Alanine aminotransferase increased13.03.04.005--
Alopecia23.02.02.001--
Amnesia17.03.02.001; 19.20.01.001--
Angioedema10.01.05.009; 22.04.02.008; 23.04.01.001---
Anxiety19.06.02.002--
Arrhythmia02.03.02.001---
Arthralgia15.01.02.001--
Aspartate aminotransferase increased13.03.04.011--
Asthenia08.01.01.001---
Asthma10.01.03.010; 22.03.01.002---
Back pain15.03.04.005--
Blood creatine increased13.13.01.001---
Blood glucose increased13.02.02.002---
Blood potassium increased13.11.01.011---
Blood triglycerides increased13.12.03.001---
Blood urea increased13.13.01.006---
Blood uric acid increased13.02.04.001---
Bradycardia02.03.02.002---
Bronchitis11.01.09.001; 22.07.01.001--
Bronchospasm10.01.03.012; 22.03.01.004--
Cardiac failure congestive02.05.01.002---
Catatonia19.11.01.001---
Chest pain02.02.02.011; 08.01.08.002; 22.12.02.003---
Colitis ischaemic07.08.01.004; 24.04.08.012---
Constipation07.02.02.001--
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