Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Bisoprolol fumarate
Drug ID BADD_D00278
Description Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs.[A180472] Bisoprolol is generally well tolerated, likely due to its β1-adrenergic receptor selectivity and is a useful alternative to non-selective β-blocker drugs in the treatment of hypertension such as [Carvedilol] and [Labetalol]. It may be used alone or in combination with other drugs to manage hypertension[L7219] and can be useful in patients with chronic obstructive pulmonary disease (COPD) due to its receptor selectivity.[A180562]
Indications and Usage For management of heart failure, angina pectoris, and mild to moderate hypertension and for secondary prevention of myocardial infarction (MI).
Marketing Status Prescription; Discontinued
ATC Code C07AB07
DrugBank ID DB00612
KEGG ID D00634
MeSH ID D017298
PubChem ID 6917733
TTD Drug ID D0K3ZR
NDC Product Code 61919-787; 52817-270; 63187-871; 68071-5097; 52817-271; 65862-087; 10920-571; 62332-603; 71335-1678; 65862-380; 65862-086; 29300-127; 65085-0051; 70954-455; 50268-127; 53747-009; 66064-1004; 52932-0720; 57451-1192; 62332-604; 38779-3142; 29300-126; 63629-6907; 70954-456; 63629-5173; 68071-1582
Synonyms Bisoprolol | Bisoprolol Fumarate (1:1) Salt, (+-)-Isomer | Bisoprolol Fumarate (2:1) Salt, (+-)-Isomer | Bisoprolol Hydrochloride | Hydrochloride, Bisoprolol | Bisoprolol Methanesulfonate Salt | Bisoprolol, (+-)-Isomer | Bisoprolol, Fumarate (1:1) Salt | Bisoprolol, Fumarate (2:1) Salt | CL-297939 | CL 297939 | CL297939 | Concor | EMD-33512 | EMD 33512 | EMD33512 | Bisoprolol Fumarate | Fumarate, Bisoprolol | Bisoprolol, (-)-Isomer
Chemical Information
Molecular Formula C22H35NO8
CAS Registry Number 104344-23-2
SMILES CC(C)NCC(COC1=CC=C(C=C1)COCCOC(C)C)O.C(=CC(=O)O)C(=O)O
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.003--
Abnormal dreams17.15.02.001; 19.02.03.001--Not Available
Acne23.02.01.001--Not Available
Agranulocytosis01.02.03.001--Not Available
Alanine aminotransferase increased13.03.01.003--
Alopecia23.02.02.001--
Amnesia17.03.02.001; 19.20.01.001--
Angioedema10.01.05.009; 23.04.01.001--Not Available
Anxiety19.06.02.002--
Arrhythmia02.03.02.001--Not Available
Arthralgia15.01.02.001--
Aspartate aminotransferase increased13.03.01.006--
Asthenia08.01.01.001--Not Available
Asthma10.01.03.010; 22.03.01.002--Not Available
Back pain15.03.04.005--
Blood creatine increased13.13.01.001--Not Available
Blood glucose increased13.02.02.002--Not Available
Blood potassium increased13.11.01.011--Not Available
Blood triglycerides increased13.12.03.001--Not Available
Blood urea increased13.13.01.006--Not Available
Blood uric acid increased13.02.04.001--Not Available
Bradycardia02.03.02.002--Not Available
Bronchitis11.01.09.001; 22.07.01.001--
Bronchospasm10.01.03.012; 22.03.01.004--
Cardiac failure congestive02.05.01.002--Not Available
Catatonia19.11.01.001--Not Available
Chest pain02.02.02.011; 08.01.08.002; 22.02.08.003--Not Available
Colitis ischaemic07.08.01.004; 24.04.08.012--Not Available
Constipation07.02.02.001--
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