Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Orthostatic intolerance
ADR ID BADD_A06213
ADR Hierarchy
02      Cardiac disorders
02.11      Cardiac disorders, signs and symptoms NEC
02.11.01      Cardiac disorders NEC
02.11.01.019      Orthostatic intolerance
24      Vascular disorders
24.06      Decreased and nonspecific blood pressure disorders and shock
24.06.01      Blood pressure disorders NEC
24.06.01.003      Orthostatic intolerance
17      Nervous system disorders
17.05      Neuromuscular disorders
17.05.01      Autonomic nervous system disorders
17.05.01.007      Orthostatic intolerance
Description Symptoms of cerebral hypoperfusion or autonomic overaction which develop while the subject is standing, but are relieved on recumbency. Types of this include NEUROCARDIOGENIC SYNCOPE; POSTURAL ORTHOSTATIC TACHYCARDIA SYNDROME; and neurogenic ORTHOSTATIC HYPOTENSION. (From Noseworthy, JH., Neurological Therapeutics Principles and Practice, 2007, p2575-2576) [MeSH]
MedDRA Code 10063927
MeSH ID D054971
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Orthostatic intolerance | Orthostatic dysregulation | Orthostatic Intolerance | Intolerance, Orthostatic
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00066Alendronic acid0.000044%
BADD_D00129Amoxicillin0.000005%
BADD_D00732Droxidopa0.000803%
BADD_D00809Escitalopram0.000038%
BADD_D00979Furosemide0.000014%
BADD_D01046Guanfacine0.000346%
BADD_D01300Lisinopril0.000005%
BADD_D01323Losartan potassium--
BADD_D01431Methylphenidate0.000041%
BADD_D01668Pantoprazole0.000025%
BADD_D01831Prednisolone0.000052%
BADD_D01954Rivaroxaban0.000095%
BADD_D02241Tolcapone--
BADD_D02247Topiramate0.000312%
BADD_D02254Tramadol--
BADD_D02261Tranexamic acid0.003117%
BADD_D02373Warfarin0.000028%
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