Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Tranexamic acid
Drug ID BADD_D02261
Description Tranexamic acid is a synthetic derivative of [lysine] used as an antifibrinolytic in the treatment and prevention of major bleeding. It possesses a similar mechanism of action to [aminocaproic acid] but is approximately 10-fold more potent.[L31883] It was first patented in 1957[A230108] and received its initial US approval in 1986.[L31858]
Indications and Usage Dunn CJ, Goa KL: Tranexamic acid: a review of its use in surgery and other indications. Drugs. 1999 Jun;57(6):1005-32.
Marketing Status Prescription; Discontinued
ATC Code B02AA02
DrugBank ID DB00302
KEGG ID D01136
MeSH ID D014148
PubChem ID 5526
TTD Drug ID D05HXX
NDC Product Code 12079-2001; 71052-166; 42571-314; 51754-0108; 67457-197; 71335-1957; 69918-301; 60505-6169; 70860-400; 0591-3720; 63629-8838; 67850-041; 50090-5072; 0013-1114; 51552-0513; 38779-3211; 42571-189; 49452-7877; 67850-042; 81999-0001; 43066-008; 72485-107; 68382-891; 39822-1000; 55150-188; 72611-760; 50090-4530; 49452-7876; 12848-1004; 71335-1981; 70121-1398; 51662-1532; 65388-0156; 61990-0611; 63323-563; 65145-106; 23155-166; 38779-2794; 81284-611; 70771-1085; 73309-178; 57218-951; 63629-8599; 51927-0022; 63759-0038; 62991-3131; 69918-300; 17478-017; 0517-0960; 81284-612; 17478-018; 62559-265; 68083-160; 55566-2110; 23155-524
Synonyms Tranexamic Acid | AMCHA | trans-4-(Aminomethyl)cyclohexanecarboxylic Acid | t-AMCHA | AMCA | Anvitoff | Cyklokapron | Ugurol | KABI 2161 | Spotof | Transamin | Amchafibrin | Exacyl
Chemical Information
Molecular Formula C8H15NO2
CAS Registry Number 701-54-2
SMILES C1CC(CCC1CN)C(=O)O
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.003--
Abdominal tenderness07.01.05.004--Not Available
Acute myocardial infarction02.02.02.001; 24.04.04.0010.057154%Not Available
Acute sinusitis11.01.13.012; 22.07.03.013--Not Available
Agitation17.02.05.012; 19.06.02.001--
Anaemia01.03.02.001--
Anaphylactic reaction10.01.07.001; 24.06.03.0060.064298%
Anaphylactic shock10.01.07.002; 24.06.02.0040.014288%Not Available
Anaphylactoid reaction10.01.07.003; 24.06.03.007--Not Available
Aneurysm24.02.01.001--Not Available
Angina pectoris02.02.02.002; 24.04.04.002--
Anxiety19.06.02.002--
Aortic dissection24.02.03.002--Not Available
Aphasia17.02.03.001; 19.21.01.0010.014288%
Arrhythmia02.03.02.0010.035721%Not Available
Arterial thrombosis24.01.01.0020.028577%Not Available
Arthralgia15.01.02.0010.035721%
Asthenia08.01.01.001--Not Available
Atrial fibrillation02.03.03.0020.128596%
Atrioventricular block02.03.01.002--Not Available
Atrioventricular block complete02.03.01.0030.014288%
Back pain15.03.04.0050.057154%
Blindness unilateral06.02.02.009; 17.17.01.0160.014288%Not Available
Blood pressure abnormal13.14.03.0010.021433%Not Available
Blood pressure decreased13.14.03.0020.021433%Not Available
Blood pressure increased13.14.03.005--Not Available
Bronchospasm10.01.03.012; 22.03.01.0040.005591%
Cardiac arrest02.03.04.0010.027956%
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