Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Brain death
ADR ID BADD_A04786
ADR Hierarchy
08      General disorders and administration site conditions
08.04      Fatal outcomes
08.04.01      Death and sudden death
08.04.01.004      Brain death
17      Nervous system disorders
17.02      Neurological disorders NEC
17.02.03      Cortical dysfunction NEC
17.02.03.003      Brain death
Description A state of prolonged irreversible cessation of all brain activity, including lower brain stem function with the complete absence of voluntary movements, responses to stimuli, brain stem reflexes, and spontaneous respirations. Reversible conditions which mimic this clinical state (e.g., sedative overdose, hypothermia, etc.) are excluded prior to making the determination of brain death. (From Adams et al., Principles of Neurology, 6th ed, pp348-9) [MeSH]
MedDRA Code 10049054
MeSH ID D001926
ADR Severity Grade (FAERS) Not Available
ADR Severity Grade (CTCAE) Not Available
Synonym
Brain death | Brain Death | Death, Brain | Brain Dead | Brain Deads | Coma Depasse | Irreversible Coma | Coma, Irreversible
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00023Acetaminophen--
BADD_D00085Alprazolam0.000091%
BADD_D00100Ambrisentan0.000120%
BADD_D00178Atenolol0.000019%
BADD_D00209Baclofen0.000139%
BADD_D00285Bosentan0.000181%
BADD_D00312Bupropion0.000138%
BADD_D00356Carbamazepine0.000279%
BADD_D00364Carboplatin0.000112%
BADD_D00405Ceftriaxone0.008913%
BADD_D00488Clobazam0.000131%
BADD_D00504Clopidogrel--
BADD_D00560Cytarabine0.000168%
BADD_D00563Dabigatran0.001101%
BADD_D00686Diphenhydramine0.001075%
BADD_D00746Edoxaban tosylate--
BADD_D00759Eltrombopag0.000229%
BADD_D00809Escitalopram0.000038%
BADD_D00879Fentanyl0.001374%
BADD_D00981Gabapentin0.000047%
BADD_D01120Ibuprofen--
BADD_D01136Imatinib0.000112%
BADD_D01182Iopromide0.007113%
BADD_D01265Levetiracetam0.000119%
BADD_D01285Levothyroxine0.000091%
BADD_D01303Lithium carbonate0.000535%
BADD_D01304Lithium cation0.000192%
BADD_D01401Metformin0.000014%
BADD_D01405Methadone0.001326%
BADD_D01498Morphine0.000223%
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